Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/46914
Title: Prevalence of pfmdr1 alleles associated with artemether-lumefantrine tolerance/resistance in Maputo before and after the implementation of artemisinin-based combination therapy
Authors: Lobo, Elsa 
Sousa, Bruno de 
Rosa, Soraia 
Figueiredo, Paula 
Lobo, Lis 
Pateira, Sara 
Fernandes, Natércia 
Nogueira, Fátima 
Keywords: Artemisinins; Drug Combinations; Drug Resistance; Ethanolamines; Fluorenes; Haplotypes; Humans; Malaria, Falciparum; Mozambique; Multidrug Resistance-Associated Proteins; Plasmodium falciparum; Polymorphism, Single Nucleotide; Prevalence
Issue Date: 2014
Serial title, monograph or event: Malaria Journal
Volume: 13
Issue: 1
Abstract: Mozambique implemented artemisinin-based combinations therapy (ACT) using artemether-lumefantrine (AL) as the first-line treatment for uncomplicated malaria in 2009. AL remains highly efficacious, but widespread use may soon facilitate emergence of artemisinin tolerance/resistance. The prevalence of pfmdr1 different alleles in Maputo and Mozambique is not known, either after or before the introduction of ACT. Pfmdr1 molecular markers related to Plasmodium falciparum susceptibility were analysed before and after transition to ACT.
URI: http://hdl.handle.net/10316/46914
DOI: 10.1186/1475-2875-13-300
Rights: openAccess
Appears in Collections:I&D CINEICC - Artigos em Revistas Internacionais

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