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https://hdl.handle.net/10316/46914| Title: | Prevalence of pfmdr1 alleles associated with artemether-lumefantrine tolerance/resistance in Maputo before and after the implementation of artemisinin-based combination therapy | Authors: | Lobo, Elsa Sousa, Bruno de Rosa, Soraia Figueiredo, Paula Lobo, Lis Pateira, Sara Fernandes, Natércia Nogueira, Fátima |
Keywords: | Artemisinins; Drug Combinations; Drug Resistance; Ethanolamines; Fluorenes; Haplotypes; Humans; Malaria, Falciparum; Mozambique; Multidrug Resistance-Associated Proteins; Plasmodium falciparum; Polymorphism, Single Nucleotide; Prevalence | Issue Date: | 2014 | Serial title, monograph or event: | Malaria Journal | Volume: | 13 | Issue: | 1 | Abstract: | Mozambique implemented artemisinin-based combinations therapy (ACT) using artemether-lumefantrine (AL) as the first-line treatment for uncomplicated malaria in 2009. AL remains highly efficacious, but widespread use may soon facilitate emergence of artemisinin tolerance/resistance. The prevalence of pfmdr1 different alleles in Maputo and Mozambique is not known, either after or before the introduction of ACT. Pfmdr1 molecular markers related to Plasmodium falciparum susceptibility were analysed before and after transition to ACT. | URI: | https://hdl.handle.net/10316/46914 | DOI: | 10.1186/1475-2875-13-300 | Rights: | openAccess |
| Appears in Collections: | I&D CINEICC - Artigos em Revistas Internacionais |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 2014_Lobo_et_al.pdf | 468.09 kB | Adobe PDF | View/Open |
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