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Title: Nucleic acid oxidation in Alzheimer disease
Authors: Moreira, Paula I. 
Nunomura, Akihiko 
Nakamura, Masao 
Takeda, Atsushi 
Shenk, Justin C. 
Aliev, Gjumrakch 
Smith, Mark A. 
Perry, George 
Keywords: Alzheimer's disease; DNA oxidation; DNA repair; Oxidative stress; RNA damage; RNA repair; Free radicals
Issue Date: 2008
Citation: Free Radical Biology and Medicine. 44:8 (2008) 1493-1505
Abstract: Increasing evidence suggests that oxidative stress is intimately associated with Alzheimer disease pathophysiology. Nucleic acids (nuclear DNA, mitochondrial DNA, and RNA) are one of the several cellular macromolecules damaged by reactive oxygen species, particularly the hydroxyl radical. Because neurons are irreplaceable and survive as long as the organism does, they need elaborate defense mechanisms to ensure their longevity. In Alzheimer disease, however, an accumulation of nucleic acid oxidation is observed, indicating an increased level of oxidative stress and/or a decreased capacity to repair the nucleic acid damage. In this review, we present data supporting the notion that mitochondrial and metal abnormalities are key sources of oxidative stress in Alzheimer disease. Furthermore, we outline the mechanisms of nucleic acid oxidation and repair. Finally, evidence showing the occurrence of nucleic acid oxidation in Alzheimer disease will be discussed.
DOI: 10.1016/j.freeradbiomed.2008.01.002
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

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