Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/4683
Title: | Nucleic acid oxidation in Alzheimer disease | Authors: | Moreira, Paula I. Nunomura, Akihiko Nakamura, Masao Takeda, Atsushi Shenk, Justin C. Aliev, Gjumrakch Smith, Mark A. Perry, George |
Keywords: | Alzheimer's disease; DNA oxidation; DNA repair; Oxidative stress; RNA damage; RNA repair; Free radicals | Issue Date: | 2008 | Citation: | Free Radical Biology and Medicine. 44:8 (2008) 1493-1505 | Abstract: | Increasing evidence suggests that oxidative stress is intimately associated with Alzheimer disease pathophysiology. Nucleic acids (nuclear DNA, mitochondrial DNA, and RNA) are one of the several cellular macromolecules damaged by reactive oxygen species, particularly the hydroxyl radical. Because neurons are irreplaceable and survive as long as the organism does, they need elaborate defense mechanisms to ensure their longevity. In Alzheimer disease, however, an accumulation of nucleic acid oxidation is observed, indicating an increased level of oxidative stress and/or a decreased capacity to repair the nucleic acid damage. In this review, we present data supporting the notion that mitochondrial and metal abnormalities are key sources of oxidative stress in Alzheimer disease. Furthermore, we outline the mechanisms of nucleic acid oxidation and repair. Finally, evidence showing the occurrence of nucleic acid oxidation in Alzheimer disease will be discussed. | URI: | https://hdl.handle.net/10316/4683 | DOI: | 10.1016/j.freeradbiomed.2008.01.002 | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
file19d9b1a892a44ca1a76bee108f356647.pdf | 355.94 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
182
checked on Oct 7, 2024
WEB OF SCIENCETM
Citations
171
checked on Oct 2, 2024
Page view(s) 50
507
checked on Oct 8, 2024
Download(s) 20
1,085
checked on Oct 8, 2024
Google ScholarTM
Check
Altmetric
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.