Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/4683
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Moreira, Paula I. | - |
dc.contributor.author | Nunomura, Akihiko | - |
dc.contributor.author | Nakamura, Masao | - |
dc.contributor.author | Takeda, Atsushi | - |
dc.contributor.author | Shenk, Justin C. | - |
dc.contributor.author | Aliev, Gjumrakch | - |
dc.contributor.author | Smith, Mark A. | - |
dc.contributor.author | Perry, George | - |
dc.date.accessioned | 2008-09-01T14:12:40Z | - |
dc.date.available | 2008-09-01T14:12:40Z | - |
dc.date.issued | 2008 | en_US |
dc.identifier.citation | Free Radical Biology and Medicine. 44:8 (2008) 1493-1505 | en_US |
dc.identifier.uri | https://hdl.handle.net/10316/4683 | - |
dc.description.abstract | Increasing evidence suggests that oxidative stress is intimately associated with Alzheimer disease pathophysiology. Nucleic acids (nuclear DNA, mitochondrial DNA, and RNA) are one of the several cellular macromolecules damaged by reactive oxygen species, particularly the hydroxyl radical. Because neurons are irreplaceable and survive as long as the organism does, they need elaborate defense mechanisms to ensure their longevity. In Alzheimer disease, however, an accumulation of nucleic acid oxidation is observed, indicating an increased level of oxidative stress and/or a decreased capacity to repair the nucleic acid damage. In this review, we present data supporting the notion that mitochondrial and metal abnormalities are key sources of oxidative stress in Alzheimer disease. Furthermore, we outline the mechanisms of nucleic acid oxidation and repair. Finally, evidence showing the occurrence of nucleic acid oxidation in Alzheimer disease will be discussed. | en_US |
dc.description.uri | http://www.sciencedirect.com/science/article/B6T38-4RM7MWS-3/1/07d7e5640ecf31a878beade229f57950 | en_US |
dc.format.mimetype | aplication/PDF | en |
dc.language.iso | eng | eng |
dc.rights | openAccess | eng |
dc.subject | Alzheimer's disease | en_US |
dc.subject | DNA oxidation | en_US |
dc.subject | DNA repair | en_US |
dc.subject | Oxidative stress | en_US |
dc.subject | RNA damage | en_US |
dc.subject | RNA repair | en_US |
dc.subject | Free radicals | en_US |
dc.title | Nucleic acid oxidation in Alzheimer disease | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1016/j.freeradbiomed.2008.01.002 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0001-5177-6747 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
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file19d9b1a892a44ca1a76bee108f356647.pdf | 355.94 kB | Adobe PDF | View/Open |
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