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https://hdl.handle.net/10316/45373| Title: | The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents | Authors: | Ferreira, José Augusto Gonçalves, Lino Naghipoor, Jahed Oliveira, Paula de Rabczuk, Timon |
Keywords: | Absorbable Implants; Antineoplastic Agents; Arteries; Paclitaxel; Plaque, Atherosclerotic; Sirolimus; Drug-Eluting Stents; Models, Theoretical | Issue Date: | 2017 | Publisher: | Elsevier | Project: | info:eu-repo/grantAgreement/FCT/5876/147205/PT | Serial title, monograph or event: | Mathematical Biosciences | Volume: | 283 | Abstract: | In this paper the effect of plaque composition, on the accumulation of drug released by a drug eluting stent, is analyzed. The mathematical model is represented by two coupled systems of partial differential equations that describe the pharmacokinetics of drug in the stent coating and in the arterial wall. The influence of the stiffness and porosity of soft and hard plaques is studied. A case study based on optical coherence tomography images is also included. | URI: | https://hdl.handle.net/10316/45373 | DOI: | 10.1016/j.mbs.2016.11.005 10.1016/j.mbs.2016.11.005 |
Rights: | embargoedAccess |
| Appears in Collections: | I&D CMUC - Artigos em Revistas Internacionais |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| PAPER2pdf.pdf | 3.85 MB | Adobe PDF | View/Open |
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