Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/45373
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ferreira, José Augusto | - |
dc.contributor.author | Gonçalves, Lino | - |
dc.contributor.author | Naghipoor, Jahed | - |
dc.contributor.author | Oliveira, Paula de | - |
dc.contributor.author | Rabczuk, Timon | - |
dc.date.accessioned | 2017-12-21T14:35:45Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://hdl.handle.net/10316/45373 | - |
dc.description.abstract | In this paper the effect of plaque composition, on the accumulation of drug released by a drug eluting stent, is analyzed. The mathematical model is represented by two coupled systems of partial differential equations that describe the pharmacokinetics of drug in the stent coating and in the arterial wall. The influence of the stiffness and porosity of soft and hard plaques is studied. A case study based on optical coherence tomography images is also included. | por |
dc.language.iso | eng | por |
dc.publisher | Elsevier | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147205/PT | por |
dc.rights | embargoedAccess | - |
dc.subject | Absorbable Implants | por |
dc.subject | Antineoplastic Agents | por |
dc.subject | Arteries | por |
dc.subject | Paclitaxel | por |
dc.subject | Plaque, Atherosclerotic | por |
dc.subject | Sirolimus | por |
dc.subject | Drug-Eluting Stents | por |
dc.subject | Models, Theoretical | por |
dc.title | The influence of atherosclerotic plaques on the pharmacokinetics of a drug eluted from bioabsorbable stents | por |
dc.type | article | - |
degois.publication.firstPage | 71 | por |
degois.publication.lastPage | 83 | por |
degois.publication.title | Mathematical Biosciences | por |
dc.relation.publisherversion | https://doi.org/10.1016/j.mbs.2016.11.005 | por |
dc.peerreviewed | yes | por |
dc.identifier.doi | 10.1016/j.mbs.2016.11.005 | por |
dc.identifier.doi | 10.1016/j.mbs.2016.11.005 | - |
degois.publication.volume | 283 | por |
dc.date.embargo | 2018-12-21T14:35:45Z | - |
uc.controloAutoridade | Sim | - |
item.fulltext | Com Texto completo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
crisitem.author.dept | Faculty of Sciences and Technology | - |
crisitem.author.dept | Faculty of Sciences and Technology | - |
crisitem.author.parentdept | University of Coimbra | - |
crisitem.author.parentdept | University of Coimbra | - |
crisitem.author.researchunit | CMUC - Centre for Mathematics of the University of Coimbra | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | CMUC - Centre for Mathematics of the University of Coimbra | - |
crisitem.author.orcid | 0000-0002-5226-2905 | - |
crisitem.author.orcid | 0000-0001-9255-3064 | - |
crisitem.author.orcid | 0000-0001-6634-6651 | - |
Appears in Collections: | I&D CMUC - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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PAPER2pdf.pdf | 3.85 MB | Adobe PDF | View/Open |
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