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https://hdl.handle.net/10316/45111
Title: | A glycine ruthenium trithiacyclononane complex and its molecular encapsulation using cyclodextrins | Authors: | Marques, Joana Santos, Teresa M. Marques, Maria Paula Braga, Susana S. |
Keywords: | Antineoplastic Agents; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Coordination Complexes; Glycine; Humans; Osteosarcoma; beta-Cyclodextrins | Issue Date: | 2009 | Serial title, monograph or event: | Dalton Transactions | Issue: | 44 | Abstract: | The complex Ru([9]aneS(3))(gly)Cl (gly = glycine) was obtained from the reaction of the precursor Ru([9]aneS(3))dmsoCl(2) with glycine and encapsulated into native beta-CD, a hydroxypropylated derivative HPbetaCD, and the methylated cyclodextrins TRIMEB and CRYSMEB. All four inclusion compounds were obtained with a 1:1 host:guest stoichiometry and characterised in the solid-state by powder X-ray diffraction, thermogravimetric analysis (TGA), and (13)C{(1)H} CP/MAS NMR and FTIR spectroscopies. The cytostatic and antiproliferative activity of the complex Ru([9]aneS(3))(gly)Cl and its four CD inclusion compounds was tested on the human osteosarcoma MG-63 cell line and the results compared to the inhibitory effect exerted by the pure cyclodextrins. | URI: | https://hdl.handle.net/10316/45111 | DOI: | 10.1039/b915839a 10.1039/b915839a |
Rights: | openAccess |
Appears in Collections: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais |
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Dalton_09_9812.pdf | 601.22 kB | Adobe PDF | View/Open |
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