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Título: | β-adrenergic over-stimulation and cardio-myocyte apoptosis: two receptors, one organelle, two fates? | Autor: | Branco, Ana F. Moreira, Ana C. Cunha-Oliveira, Teresa Couto, Renata Sardão, Vilma A. Rizvanov, Albert A. Palotas, Andras Oliveira, Paulo J. |
Palavras-chave: | Animals; Calcium; Catecholamines; Humans; Mitochondria; Myocytes, Cardiac; Reactive Oxygen Species; Receptors, Adrenergic, beta; Signal Transduction; Apoptosis | Data: | 2014 | Projeto: | info:eu-repo/grantAgreement/FCT/5876-PPCDTI/117912/PT PEst-C/SAU/LA0001/ 2013-2014 CENTRO-07-ST24-FEDER-002008 |
Título da revista, periódico, livro ou evento: | Current drug targets | Volume: | 15 | Número: | 10 | Resumo: | Neuro-hormonal regulation of cardiac function via cathecol-amines results in increased heart rate and contractility. A persistent adrenergic tone, however, is an insult to the heart, affecting its regular homeostasis, altering morphology and gene expression patterns, as well as inducing apoptosis of cardio-myocytes. At the same time as being the main oxygen consumers, mitochondria are also key to the energy production required for the heart to maintain its vital functions and to integrate a series of signaling pathways that define the life and death of the cell. As α-adrenergic receptors (α-AR) orchestrate multiple biochemical events that can either trigger or inhibit cell death, mitochondria can act as a referee in the entire process. In fact, α-AR subtypes α1 and α2 activate various down-stream pathways which differently modulate intracellular calcium levels and production of mitochondrial reactive oxygen species (ROS). The delicate balance between an adaptive (cardio-protective) response resulting in increased contractility and activation of survival pathways, vs. cell death caused by calcium and ROS-induced mitochondrial disruption, along with evidence of their clinical and potential therapeutic translations, are reviewed in this communication. | URI: | https://hdl.handle.net/10316/44868 | Direitos: | openAccess |
Aparece nas coleções: | I&D CNC - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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23_Branco et al Curr Drug Targets 2014.pdf | 1.41 MB | Adobe PDF | Ver/Abrir |
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