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https://hdl.handle.net/10316/42069
Title: | Association of polymorphisms in 5-HTT (SLC6A4) and MAOA genes with measures of obesity in young adults of Portuguese origin | Authors: | Dias, Helena Muc, Magdalena Padez, Cristina Manco, Licínio |
Keywords: | 5-HTTLPR and STin2 polymorphisms,; MAOA VNTR polymorphism,; serotonin transporter,; overweight and obesity,; Portugal | Issue Date: | 2016 | Project: | info:eu-repo/grantAgreement/FCT/5876/147309/PT | Serial title, monograph or event: | Archives of Physiology and Biochemistry | Volume: | 122 | Issue: | 1 | Abstract: | Objectives: To investigate the association of polymorphisms in SLC6A4 and MAOA genes with overweight (including obesity). Material and methods: Young adults (n = 535) of Portuguese origin were genotyped for the SLC6A4 polymorphisms 5-HTTLPR and STin2 and a MAOA VNTR. BMI and body fat percentage were measured and a questionnaire was used to assess individual’s sport practicing habits. Results: In whole study sample, haplotype-based analysis revealed significant association with overweight/obesity for the individual 5-HTTLPR/Stin2 haplotype L10 (p = 0.04). In men, the MAOA 3R genotype was nominally associated with body fat (p = 0.04). In inactive individuals, overweight/obesity was found significantly associated with 5-HTTLPR L-allele (p = 0.01) and nominally associated with STin2 10-allele (p = 0.03). A significant association was also found testing for all haplotype effects (χ2 = 8.7; p = 0.03). Conclusions: We found some evidences for the association of SLC6A4 and MAOA genes with measures of obesity. Our results suggest physical inactivity accentuates the influence of SLC6A4 polymorphisms on obesity risk. | URI: | https://hdl.handle.net/10316/42069 | DOI: | 10.3109/13813455.2015.1111390 | Rights: | openAccess |
Appears in Collections: | I&D CIAS - Artigos em Revistas Internacionais |
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