Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/42069
DC Field | Value | Language |
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dc.contributor.author | Dias, Helena | - |
dc.contributor.author | Muc, Magdalena | - |
dc.contributor.author | Padez, Cristina | - |
dc.contributor.author | Manco, Licínio | - |
dc.date.accessioned | 2017-06-22T16:13:14Z | |
dc.date.accessioned | 2018-01-10T16:45:58Z | - |
dc.date.available | 2017-06-22T16:13:14Z | |
dc.date.available | 2018-01-10T16:45:58Z | - |
dc.date.issued | 2016 | |
dc.identifier.uri | https://hdl.handle.net/10316/42069 | |
dc.description.abstract | Objectives: To investigate the association of polymorphisms in SLC6A4 and MAOA genes with overweight (including obesity). Material and methods: Young adults (n = 535) of Portuguese origin were genotyped for the SLC6A4 polymorphisms 5-HTTLPR and STin2 and a MAOA VNTR. BMI and body fat percentage were measured and a questionnaire was used to assess individual’s sport practicing habits. Results: In whole study sample, haplotype-based analysis revealed significant association with overweight/obesity for the individual 5-HTTLPR/Stin2 haplotype L10 (p = 0.04). In men, the MAOA 3R genotype was nominally associated with body fat (p = 0.04). In inactive individuals, overweight/obesity was found significantly associated with 5-HTTLPR L-allele (p = 0.01) and nominally associated with STin2 10-allele (p = 0.03). A significant association was also found testing for all haplotype effects (χ2 = 8.7; p = 0.03). Conclusions: We found some evidences for the association of SLC6A4 and MAOA genes with measures of obesity. Our results suggest physical inactivity accentuates the influence of SLC6A4 polymorphisms on obesity risk. | por |
dc.language.iso | por | por |
dc.relation | info:eu-repo/grantAgreement/FCT/5876/147309/PT | por |
dc.rights | openAccess | por |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | por |
dc.subject | 5-HTTLPR and STin2 polymorphisms, | por |
dc.subject | MAOA VNTR polymorphism, | por |
dc.subject | serotonin transporter, | por |
dc.subject | overweight and obesity, | por |
dc.subject | Portugal | por |
dc.title | Association of polymorphisms in 5-HTT (SLC6A4) and MAOA genes with measures of obesity in young adults of Portuguese origin | por |
dc.type | article | |
degois.publication.firstPage | 8 | por |
degois.publication.lastPage | 13 | por |
degois.publication.issue | 1 | por |
degois.publication.title | Archives of Physiology and Biochemistry | por |
dc.relation.publisherversion | http://www.tandfonline.com/doi/full/10.3109/13813455.2015.1111390?scroll=top&needAccess=true | por |
dc.peerreviewed | yes | por |
dc.identifier.doi | 10.3109/13813455.2015.1111390 | - |
degois.publication.volume | 122 | por |
uc.controloAutoridade | Sim | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | pt | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CIAS - Research Centre for Anthropology and Health | - |
crisitem.author.researchunit | CIAS - Research Centre for Anthropology and Health | - |
crisitem.author.orcid | 0000-0002-1967-3497 | - |
crisitem.author.orcid | 0000-0002-2636-0288 | - |
Appears in Collections: | I&D CIAS - Artigos em Revistas Internacionais |
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cias2016_31.pdf | 729.59 kB | Adobe PDF | View/Open |
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