Title: Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors
Authors: Moreira, Vânia M. A. 
Vasaitis, Tadas S. 
Njar, Vincent C. O. 
Salvador, Jorge A. R. 
Keywords: Indazole;CYP17;Prostate cancer;Androgen receptor;PC cell lines
Issue Date: Dec-2007
Citation: MOREIRA, Vânia M.A.; VASAITIS, Tadas S.; NJAR, Vincent C.O.; SALVADOR, Jorge A.R. - Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors. Steroids 72:14 (2007) 939-948.
Abstract: A series of novel 1H- and 2H-indazole derivatives of the commercially available dehydroepiandrosterone acetate have been synthesized and tested for inhibition of human cytochrome 17 -hydroxylase-C17,20-lyase (CYP17), androgen receptor (AR) binding affinity, and cytotoxic potential against three prostate cancer (PC) cell lines.
URI: http://hdl.handle.net/10316/2792
Rights: openAccess
Appears in Collections:FFUC- Artigos em Revistas Internacionais

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