Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/2792
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dc.contributor.authorMoreira, Vânia M. A.-
dc.contributor.authorVasaitis, Tadas S.-
dc.contributor.authorNjar, Vincent C. O.-
dc.contributor.authorSalvador, Jorge A. R.-
dc.date.accessioned2008-07-01T16:42:08Z-
dc.date.available2008-07-01T16:42:08Z-
dc.date.issued2007-12-
dc.identifier.citationMOREIRA, Vânia M.A.; VASAITIS, Tadas S.; NJAR, Vincent C.O.; SALVADOR, Jorge A.R. - Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors. Steroids 72:14 (2007) 939-948.en_US
dc.identifier.urihttps://hdl.handle.net/10316/2792-
dc.description.abstractA series of novel 1H- and 2H-indazole derivatives of the commercially available dehydroepiandrosterone acetate have been synthesized and tested for inhibition of human cytochrome 17 -hydroxylase-C17,20-lyase (CYP17), androgen receptor (AR) binding affinity, and cytotoxic potential against three prostate cancer (PC) cell lines.en_US
dc.format.mimetypeaplication/PDFen
dc.language.isoengen_US
dc.rightsopenAccesseng
dc.subjectIndazoleen_US
dc.subjectCYP17en_US
dc.subjectProstate canceren_US
dc.subjectAndrogen receptoren_US
dc.subjectPC cell linesen_US
dc.titleSynthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitorsen_US
dc.typearticleen_US
dc.identifier.doi10.1016/j.steroids.2007.08.004-
item.grantfulltextopen-
item.fulltextCom Texto completo-
item.openairetypearticle-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.orcid0000-0001-6169-5035-
crisitem.author.orcid0000-0003-0779-6083-
Appears in Collections:FFUC- Artigos em Revistas Internacionais
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