Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/2792| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Moreira, Vânia M. A. | - |
| dc.contributor.author | Vasaitis, Tadas S. | - |
| dc.contributor.author | Njar, Vincent C. O. | - |
| dc.contributor.author | Salvador, Jorge A. R. | - |
| dc.date.accessioned | 2008-07-01T16:42:08Z | - |
| dc.date.available | 2008-07-01T16:42:08Z | - |
| dc.date.issued | 2007-12 | - |
| dc.identifier.citation | MOREIRA, Vânia M.A.; VASAITIS, Tadas S.; NJAR, Vincent C.O.; SALVADOR, Jorge A.R. - Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors. Steroids 72:14 (2007) 939-948. | en_US |
| dc.identifier.uri | https://hdl.handle.net/10316/2792 | - |
| dc.description.abstract | A series of novel 1H- and 2H-indazole derivatives of the commercially available dehydroepiandrosterone acetate have been synthesized and tested for inhibition of human cytochrome 17 -hydroxylase-C17,20-lyase (CYP17), androgen receptor (AR) binding affinity, and cytotoxic potential against three prostate cancer (PC) cell lines. | en_US |
| dc.format.mimetype | aplication/PDF | en |
| dc.language.iso | eng | en_US |
| dc.rights | openAccess | eng |
| dc.subject | Indazole | en_US |
| dc.subject | CYP17 | en_US |
| dc.subject | Prostate cancer | en_US |
| dc.subject | Androgen receptor | en_US |
| dc.subject | PC cell lines | en_US |
| dc.title | Synthesis and evaluation of novel 17-indazole androstene derivatives designed as CYP17 inhibitors | en_US |
| dc.type | article | en_US |
| dc.identifier.doi | 10.1016/j.steroids.2007.08.004 | - |
| item.fulltext | Com Texto completo | - |
| item.grantfulltext | open | - |
| item.languageiso639-1 | en | - |
| item.cerifentitytype | Publications | - |
| item.openairetype | article | - |
| item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
| crisitem.author.researchunit | CQC - Coimbra Chemistry Centre | - |
| crisitem.author.parentresearchunit | Faculty of Sciences and Technology | - |
| crisitem.author.orcid | 0000-0001-6169-5035 | - |
| crisitem.author.orcid | 0000-0003-0779-6083 | - |
| Appears in Collections: | FFUC- Artigos em Revistas Internacionais | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Synthesis and evaluation.pdf | 608.88 kB | Adobe PDF | View/Open |
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