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https://hdl.handle.net/10316/12669
Título: | A linkage study between the GABAA beta2 and GABAA gamma2 subunit genes and major psychoses | Autor: | Ambrósio, Alda M. Kennedy, James L. Macciardi, Fabio King, Nicole Azevedo, Maria H. Oliveira, Catarina R. Pato, Carlos N. |
Data: | Jan-2005 | Editora: | MBL Communications, Inc | Citação: | CNS Spectrums. 10:1 (2005) 57-61 | Resumo: | Background: Alterations of the γ-aminobutyric acid (GABA) system have been implicated in the pathophysiology of major psychoses. Objective: Restriction fragment length polymorphisms associated with the human γ-aminobutyric acid type A (GABAA) β2 and GABAA γ2 subunit genes on chromosome 5q32-q35 were tested to determine whether they confer susceptibility to major psychoses. Methods: Thirty-two schizophrenic families and 25 bipolar families were tested for linkage. Results: Nonparametric linkage (NPL) analysis performed by GENEHUNTER showed no significant NPL scores for both genes in schizophrenia (GABAA β2: NPL narrow=–0.450; NPL broad=–0.808; GABAA γ2: NPL narrow=0.177; NPL broad=–0.051) or bipolar disorder (GABAA β2: NPL narrow=0.834; NPL broad=0.783; GABAA γ2: NPL narrow=–0.159; NPL broad=0.070). Conclusion: Linkage analysis does not support the hypothesis that variants within the GABAA β2 and GABAA γ2 genes are significantly linked to major psychoses in a Portuguese population | URI: | https://hdl.handle.net/10316/12669 | ISSN: | 1092-8529 | DOI: | 10.1017/s1092852900009913 | Direitos: | openAccess |
Aparece nas coleções: | FFUC- Artigos em Revistas Internacionais |
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Ficheiro | Descrição | Tamanho | Formato | |
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A linkage study between the GABAA beta2 and GABAA gamma2.pdf | 179.43 kB | Adobe PDF | Ver/Abrir |
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