Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/12669
DC Field | Value | Language |
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dc.contributor.author | Ambrósio, Alda M. | - |
dc.contributor.author | Kennedy, James L. | - |
dc.contributor.author | Macciardi, Fabio | - |
dc.contributor.author | King, Nicole | - |
dc.contributor.author | Azevedo, Maria H. | - |
dc.contributor.author | Oliveira, Catarina R. | - |
dc.contributor.author | Pato, Carlos N. | - |
dc.date.accessioned | 2010-03-03T15:12:52Z | - |
dc.date.available | 2010-03-03T15:12:52Z | - |
dc.date.issued | 2005-01 | - |
dc.identifier.citation | CNS Spectrums. 10:1 (2005) 57-61 | en_US |
dc.identifier.issn | 1092-8529 | - |
dc.identifier.uri | https://hdl.handle.net/10316/12669 | - |
dc.description.abstract | Background: Alterations of the γ-aminobutyric acid (GABA) system have been implicated in the pathophysiology of major psychoses. Objective: Restriction fragment length polymorphisms associated with the human γ-aminobutyric acid type A (GABAA) β2 and GABAA γ2 subunit genes on chromosome 5q32-q35 were tested to determine whether they confer susceptibility to major psychoses. Methods: Thirty-two schizophrenic families and 25 bipolar families were tested for linkage. Results: Nonparametric linkage (NPL) analysis performed by GENEHUNTER showed no significant NPL scores for both genes in schizophrenia (GABAA β2: NPL narrow=–0.450; NPL broad=–0.808; GABAA γ2: NPL narrow=0.177; NPL broad=–0.051) or bipolar disorder (GABAA β2: NPL narrow=0.834; NPL broad=0.783; GABAA γ2: NPL narrow=–0.159; NPL broad=0.070). Conclusion: Linkage analysis does not support the hypothesis that variants within the GABAA β2 and GABAA γ2 genes are significantly linked to major psychoses in a Portuguese population | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MBL Communications, Inc | en_US |
dc.rights | openAccess | en_US |
dc.title | A linkage study between the GABAA beta2 and GABAA gamma2 subunit genes and major psychoses | en_US |
dc.type | article | en_US |
dc.identifier.doi | 10.1017/s1092852900009913 | - |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.orcid | 0000-0001-6942-4328 | - |
Appears in Collections: | FFUC- Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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A linkage study between the GABAA beta2 and GABAA gamma2.pdf | 179.43 kB | Adobe PDF | View/Open |
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