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Title: Seaweeds as Nutraceutical Elements and Drugs for Diabetes Mellitus: Future Perspectives
Authors: Cotas, João 
Lomartire, Silvia 
Pereira, Leonel 
Valado, Ana 
Marques, J. 
Gonçalves, Ana Marta 
Keywords: antidiabetic agents; chemical diversity; complications; diabetes mellitus; high blood glucose levels; insulin; marine natural products; mechanisms of action; multitargeted effects; peptides; polyphenols; polysaccharides; preclinical studies; seaweeds; therapeutic potential
Issue Date: 10-Apr-2024
Publisher: MDPI
Project: info:eu-repo/grantAgreement/UIDB/04004/2020 
LA/P/0092/2020/Associate Laboratory TERRA 
info:eu-repo/grantAgreement/FCT/UIDB /04292/2020/PT 
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP/50017/2020/PT/Centre for Environmental and Marine Studies 
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB/50017/2020/PT/Centre for Environmental and Marine Studies 
FCT Doctoral grant 2021.05005.BD 
Serial title, monograph or event: Marine Drugs
Volume: 22
Issue: 4
Abstract: Diabetes mellitus is a chronic metabolic condition marked by high blood glucose levels caused by inadequate insulin synthesis or poor insulin use. This condition affects millions of individuals worldwide and is linked to a variety of consequences, including cardiovascular disease, neuropathy, nephropathy, and retinopathy. Diabetes therapy now focuses on controlling blood glucose levels through lifestyle changes, oral medicines, and insulin injections. However, these therapies have limits and may not successfully prevent or treat diabetic problems. Several marine-derived chemicals have previously demonstrated promising findings as possible antidiabetic medicines in preclinical investigations. Peptides, polyphenols, and polysaccharides extracted from seaweeds, sponges, and other marine species are among them. As a result, marine natural products have the potential to be a rich source of innovative multitargeted medications for diabetes prevention and treatment, as well as associated complications. Future research should focus on the chemical variety of marine creatures as well as the mechanisms of action of marine-derived chemicals in order to find new antidiabetic medicines and maximize their therapeutic potential. Based on preclinical investigations, this review focuses on the next step for seaweed applications as potential multitargeted medicines for diabetes, highlighting the bioactivities of seaweeds in the prevention and treatment of this illness.
ISSN: 1660-3397
DOI: 10.3390/md22040168
Rights: openAccess
Appears in Collections:I&D MARE - Artigos em Revistas Internacionais
FCTUC Ciências da Vida - Artigos em Revistas Internacionais
I&D CFE - Artigos em Revistas Internacionais

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