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https://hdl.handle.net/10316/113812
Title: | Water-Soluble Saccharina latissima Polysaccharides and Relation of Their Structural Characteristics with In Vitro Immunostimulatory and Hypocholesterolemic Activities | Authors: | Moreira, Ana S. P. Gaspar, Diana Ferreira, Sónia S. Correia, Alexandra Vilanova, Manuel João Rua Perrineau, Marie-Mathilde Kerrison, Philip D. Gachon, Claire M. M. Domingues, Maria Rosário Coimbra, Manuel A. Coreta-Gomes, Filipe M. Nunes, Cláudia |
Keywords: | seaweed; Laminariales; sulphated polysaccharides; fucans; fucoidans; mice; lymphocytes; flow cytometry; hypocholesterolemic effect; NMR | Issue Date: | 16-Mar-2023 | Publisher: | MDPI | Project: | UIDB/50006/2020 UIDP/50006/2020 UID/QUI/00313/2019 RECI/QEQ-QFI/0168/2012 UIDB/50011/2020 UIDP/50011/2020 CENTRO-07-CT62-FEDER-002012 UIDP/50017/2020 UIDB/50017/2020 LA/P/0094/2020 LISBOA-01-0145-FEDER-402-022125 UIDB/50006/2020 |
Serial title, monograph or event: | Marine Drugs | Volume: | 21 | Issue: | 3 | Abstract: | Brown macroalgae are an important source of polysaccharides, mainly fucose-containing sulphated polysaccharides (FCSPs), associated with several biological activities. However, the structural diversity and structure-function relationships for their bioactivities are still undisclosed. Thus, the aim of this work was to characterize the chemical structure of water-soluble Saccharina latissima polysaccharides and evaluate their immunostimulatory and hypocholesterolemic activities, helping to pinpoint a structure-activity relationship. Alginate, laminarans (F1, neutral glucose-rich polysaccharides), and two fractions (F2 and F3) of FCSPs (negatively charged) were studied. Whereas F2 is rich in uronic acids (45 mol%) and fucose (29 mol%), F3 is rich in fucose (59 mol%) and galactose (21 mol%). These two fractions of FCSPs showed immunostimulatory activity on B lymphocytes, which could be associated with the presence of sulphate groups. Only F2 exhibited a significant effect in reductions in in vitro cholesterol's bioaccessibility attributed to the sequestration of bile salts. Therefore, S. latissima FCSPs were shown to have potential as immunostimulatory and hypocholesterolemic functional ingredients, where their content in uronic acids and sulphation seem to be relevant for the bioactive and healthy properties. | URI: | https://hdl.handle.net/10316/113812 | ISSN: | 1660-3397 | DOI: | 10.3390/md21030183 | Rights: | openAccess |
Appears in Collections: | I&D CQC - Artigos em Revistas Internacionais |
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