Utilize este identificador para referenciar este registo: https://hdl.handle.net/10316/113274
Título: Metabolic Priming as a Tool in Redox and Mitochondrial Theragnostics
Autor: Pinho, Sónia A. 
Anjo, Sandra I. 
Cunha-Oliveira, Teresa 
Palavras-chave: metabolic priming; theragnostics; mitochondria; redox homeostasis; media composition; oxygen levels
Data: 10-Mai-2023
Editora: MDPI
Projeto: CENTRO-01-0246-FEDER-000010 
PTDC/BTM-SAL/29297/2017 
POCI-01-0145-FEDER- 029297 
UIDB/04539/2020 
info:eu-repo/grantAgreement/UIDP/04539/2020 
LA/P/0058/2020 
SFRH/PD/BD/143055/2018 
2021.04378.CEECIND 
Título da revista, periódico, livro ou evento: Antioxidants
Volume: 12
Número: 5
Resumo: Theragnostics is a promising approach that integrates diagnostics and therapeutics into a single personalized strategy. To conduct effective theragnostic studies, it is essential to create an in vitro environment that accurately reflects the in vivo conditions. In this review, we discuss the importance of redox homeostasis and mitochondrial function in the context of personalized theragnostic approaches. Cells have several ways to respond to metabolic stress, including changes in protein localization, density, and degradation, which can promote cell survival. However, disruption of redox homeostasis can lead to oxidative stress and cellular damage, which are implicated in various diseases. Models of oxidative stress and mitochondrial dysfunction should be developed in metabolically conditioned cells to explore the underlying mechanisms of diseases and develop new therapies. By choosing an appropriate cellular model, adjusting cell culture conditions and validating the cellular model, it is possible to identify the most promising therapeutic options and tailor treatments to individual patients. Overall, we highlight the importance of precise and individualized approaches in theragnostics and the need to develop accurate in vitro models that reflect the in vivo conditions.
URI: https://hdl.handle.net/10316/113274
ISSN: 2076-3921
DOI: 10.3390/antiox12051072
Direitos: openAccess
Aparece nas coleções:I&D CIBB - Artigos em Revistas Internacionais
IIIUC - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais

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