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https://hdl.handle.net/10316/112366| Title: | DNA-Interactive and Damage Study with meso-Tetra(2-thienyl)porphyrins Coordinated with Polypyridyl Pd(II) and Pt(II) Complexes | Authors: | Iglesias, Bernardo Almeida Peranzoni, Níckolas Pippi Faria, Sophia Iwersen Trentin, Luana Belo Schuch, André Passaglia Chaves, Otávio Augusto Bertoloni, Renan Ribeiro Nikolaou, Sofia de Oliveira, Kleber Thiago |
Keywords: | porphyrins; thienyl-porphyrins; Pt(II) and Pd(II) complexes; DNA; photobiology | Issue Date: | 5-Jul-2023 | Publisher: | MDPI | Project: | UIDB/00313/2020 | Serial title, monograph or event: | Molecules | Volume: | 28 | Issue: | 13 | Abstract: | We report the DNA-binding properties of three porphyrins with peripheral thienyl substituents (TThPor, PdTThPor and PtTThPor). The binding capacity of each porphyrin with DNA was determined by UV-Vis and steady-state fluorescence emission spectroscopy combined with molecular docking calculations. The results suggest that the interaction of these compounds probably occurs via secondary interactions via external grooves (minor grooves) around the DNA macromolecule. Moreover, porphyrins containing peripheral Pd(II) or Pt(II) complexes (PdTThPor and PtTThPor) were able to promote photo-damage in the DNA. | URI: | https://hdl.handle.net/10316/112366 | ISSN: | 1420-3049 | DOI: | 10.3390/molecules28135217 | Rights: | openAccess |
| Appears in Collections: | FCTUC Química - Artigos em Revistas Internacionais I&D CQC - Artigos em Revistas Internacionais |
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| DNAInteractive-and-Damage-Study-with-mesoTetra2thienylporphyrins-Coordinated-with-Polypyridyl-PdII-and-PtII-ComplexesMolecules.pdf | 2.25 MB | Adobe PDF | View/Open |
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