Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/112366
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dc.contributor.authorIglesias, Bernardo Almeida-
dc.contributor.authorPeranzoni, Níckolas Pippi-
dc.contributor.authorFaria, Sophia Iwersen-
dc.contributor.authorTrentin, Luana Belo-
dc.contributor.authorSchuch, André Passaglia-
dc.contributor.authorChaves, Otávio Augusto-
dc.contributor.authorBertoloni, Renan Ribeiro-
dc.contributor.authorNikolaou, Sofia-
dc.contributor.authorde Oliveira, Kleber Thiago-
dc.date.accessioned2024-01-30T11:20:03Z-
dc.date.available2024-01-30T11:20:03Z-
dc.date.issued2023-07-05-
dc.identifier.issn1420-3049pt
dc.identifier.urihttps://hdl.handle.net/10316/112366-
dc.description.abstractWe report the DNA-binding properties of three porphyrins with peripheral thienyl substituents (TThPor, PdTThPor and PtTThPor). The binding capacity of each porphyrin with DNA was determined by UV-Vis and steady-state fluorescence emission spectroscopy combined with molecular docking calculations. The results suggest that the interaction of these compounds probably occurs via secondary interactions via external grooves (minor grooves) around the DNA macromolecule. Moreover, porphyrins containing peripheral Pd(II) or Pt(II) complexes (PdTThPor and PtTThPor) were able to promote photo-damage in the DNA.pt
dc.language.isoengpt
dc.publisherMDPIpt
dc.relationUIDB/00313/2020pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subjectporphyrinspt
dc.subjectthienyl-porphyrinspt
dc.subjectPt(II) and Pd(II) complexespt
dc.subjectDNApt
dc.subjectphotobiologypt
dc.subject.meshMolecular Docking Simulationpt
dc.subject.meshSpectrometry, Fluorescencept
dc.subject.meshDNApt
dc.subject.meshPorphyrinspt
dc.titleDNA-Interactive and Damage Study with meso-Tetra(2-thienyl)porphyrins Coordinated with Polypyridyl Pd(II) and Pt(II) Complexespt
dc.typearticle-
degois.publication.firstPage5217pt
degois.publication.issue13pt
degois.publication.titleMoleculespt
dc.peerreviewedyespt
dc.identifier.doi10.3390/molecules28135217pt
degois.publication.volume28pt
dc.date.embargo2023-07-05*
uc.date.periodoEmbargo0pt
item.openairetypearticle-
item.fulltextCom Texto completo-
item.languageiso639-1en-
item.grantfulltextopen-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
crisitem.project.grantnoCoimbra Chemistry Center-
crisitem.author.researchunitCQC - Coimbra Chemistry Centre-
crisitem.author.parentresearchunitFaculty of Sciences and Technology-
crisitem.author.orcid0000-0001-6211-7659-
Appears in Collections:FCTUC Química - Artigos em Revistas Internacionais
I&D CQC - Artigos em Revistas Internacionais
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