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https://hdl.handle.net/10316/111766
Título: | Predicting response to chemoradiotherapy in rectal cancer via visual morphologic assessment and staging on baseline MRI: a multicenter and multireader study | Autor: | El Khababi, Najim Beets-Tan, Regina G. H. Tissier, Renaud Lahaye, Max J. Maas, Monique Semedo, Luís Curvo Dresen, Raphaëla C. Nougaret, Stephanie Beets, Geerard L. Lambregts, Doenja M. J. |
Palavras-chave: | Rectal cancer; Magnetic resonance imaging; Chemoradiotherapy; Response | Data: | Out-2023 | Editora: | Springer Nature | Projeto: | Dutch Cancer Society | Título da revista, periódico, livro ou evento: | Abdominal Radiology | Volume: | 48 | Número: | 10 | Resumo: | Purpose Pre-treatment knowledge of the anticipated response of rectal tumors to neoadjuvant chemoradiotherapy (CRT) could help to further optimize the treatment. Van Griethuysen et al. proposed a visual 5-point confidence score to predict the likelihood of response on baseline MRI. Aim was to evaluate this score in a multicenter and multireader study setting and compare it to two simplified (4-point and 2-point) adaptations in terms of diagnostic performance, interobserver agreement (IOA), and reader preference. Methods Twenty-two radiologists from 14 countries (5 MRI-experts,17 general/abdominal radiologists) retrospectively reviewed 90 baseline MRIs to estimate if patients would likely achieve a (near-)complete response (nCR); first using the 5-point score by van Griethuysen (1=highly unlikely to 5=highly likely to achieve nCR), second using a 4-point adaptation (with 1-point each for high-risk T-stage, obvious mesorectal fascia invasion, nodal involvement, and extramural vascular invasion), and third using a 2-point score (unlikely/likely to achieve nCR). Diagnostic performance was calculated using ROC curves and IOA using Krippendorf’s alpha (α). Results Areas under the ROC curve to predict the likelihood of a nCR were similar for the three methods (0.71–0.74). IOA was higher for the 5- and 4-point scores (α=0.55 and 0.57 versus 0.46 for the 2-point score) with best results for the MRIexperts (α=0.64-0.65). Most readers (55%) favored the 4-point score. | URI: | https://hdl.handle.net/10316/111766 | ISSN: | 2366-0058 | DOI: | 10.1007/s00261-023-03961-7 | Direitos: | openAccess |
Aparece nas coleções: | FMUC Medicina - Artigos em Revistas Internacionais |
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Predicting-response-to-chemoradiotherapy-in-rectal-cancer-via-visual-morphologicassessmentand-staging-on-baseline-MRI-a-multicenter-and-multireader-studyAbdominal-Radiology.pdf | 1.06 MB | Adobe PDF | Ver/Abrir |
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