Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/111766
DC Field | Value | Language |
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dc.contributor.author | El Khababi, Najim | - |
dc.contributor.author | Beets-Tan, Regina G. H. | - |
dc.contributor.author | Tissier, Renaud | - |
dc.contributor.author | Lahaye, Max J. | - |
dc.contributor.author | Maas, Monique | - |
dc.contributor.author | Semedo, Luís Curvo | - |
dc.contributor.author | Dresen, Raphaëla C. | - |
dc.contributor.author | Nougaret, Stephanie | - |
dc.contributor.author | Beets, Geerard L. | - |
dc.contributor.author | Lambregts, Doenja M. J. | - |
dc.date.accessioned | 2024-01-09T12:20:12Z | - |
dc.date.available | 2024-01-09T12:20:12Z | - |
dc.date.issued | 2023-10 | - |
dc.identifier.issn | 2366-0058 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/111766 | - |
dc.description.abstract | Purpose Pre-treatment knowledge of the anticipated response of rectal tumors to neoadjuvant chemoradiotherapy (CRT) could help to further optimize the treatment. Van Griethuysen et al. proposed a visual 5-point confidence score to predict the likelihood of response on baseline MRI. Aim was to evaluate this score in a multicenter and multireader study setting and compare it to two simplified (4-point and 2-point) adaptations in terms of diagnostic performance, interobserver agreement (IOA), and reader preference. Methods Twenty-two radiologists from 14 countries (5 MRI-experts,17 general/abdominal radiologists) retrospectively reviewed 90 baseline MRIs to estimate if patients would likely achieve a (near-)complete response (nCR); first using the 5-point score by van Griethuysen (1=highly unlikely to 5=highly likely to achieve nCR), second using a 4-point adaptation (with 1-point each for high-risk T-stage, obvious mesorectal fascia invasion, nodal involvement, and extramural vascular invasion), and third using a 2-point score (unlikely/likely to achieve nCR). Diagnostic performance was calculated using ROC curves and IOA using Krippendorf’s alpha (α). Results Areas under the ROC curve to predict the likelihood of a nCR were similar for the three methods (0.71–0.74). IOA was higher for the 5- and 4-point scores (α=0.55 and 0.57 versus 0.46 for the 2-point score) with best results for the MRIexperts (α=0.64-0.65). Most readers (55%) favored the 4-point score. | pt |
dc.language.iso | eng | pt |
dc.publisher | Springer Nature | pt |
dc.relation | Dutch Cancer Society | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Rectal cancer | pt |
dc.subject | Magnetic resonance imaging | pt |
dc.subject | Chemoradiotherapy | pt |
dc.subject | Response | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Retrospective Studies | pt |
dc.subject.mesh | Chemoradiotherapy | pt |
dc.subject.mesh | Fascia | pt |
dc.subject.mesh | Magnetic Resonance Imaging | pt |
dc.subject.mesh | Neoplasm Staging | pt |
dc.subject.mesh | Treatment Outcome | pt |
dc.subject.mesh | Rectal Neoplasms | pt |
dc.title | Predicting response to chemoradiotherapy in rectal cancer via visual morphologic assessment and staging on baseline MRI: a multicenter and multireader study | pt |
dc.type | article | - |
degois.publication.firstPage | 3039 | pt |
degois.publication.lastPage | 3049 | pt |
degois.publication.issue | 10 | pt |
degois.publication.title | Abdominal Radiology | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1007/s00261-023-03961-7 | pt |
degois.publication.volume | 48 | pt |
dc.date.embargo | 2023-10-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais |
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