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Title: Sustained drug released from contact lens
Authors: Ferreira, J. A. 
Oliveira, P. de 
Silva, P. M. da 
Carreira, A. 
Gil, H. 
Murta, J. N. 
Keywords: Ophthalmic drug delivery; Contact lenses; p-(HEMA/MAA); Reaction-diffusion equation; Qualitative behaviour; Numerical simulation; Experimental results
Issue Date: 2009
Publisher: Centro de Matemática da Universidade de Coimbra
Citation: Pré-Publicações DMUC. 09-20 (2009)
Abstract: This paper focuses on ophthalmic drug release from a loaded copolymer: the drug is dispersed in the polymeric matrix and entrapped in particles. The copolymer is based in 2-hydroxyethyl methacrylate co-methacrylic acid and silicone is used to prepare the loaded particles. A mathematical model to simulate the drug release is proposed and a qualitative analysis is performed. Experimental results are compared with simulation results. Contact lens made from the presented copolymer are expected to deliver drug at therapeutical levels for a few days.
Rights: openAccess
Appears in Collections:FMUC Medicina - Vários
FCTUC Eng.Química - Vários
FCTUC Matemática - Vários

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