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https://hdl.handle.net/10316/11167| Title: | Sustained drug released from contact lens | Authors: | Ferreira, J. A. Oliveira, P. de Silva, P. M. da Carreira, A. Gil, H. Murta, J. N. |
Keywords: | Ophthalmic drug delivery; Contact lenses; p-(HEMA/MAA); Reaction-diffusion equation; Qualitative behaviour; Numerical simulation; Experimental results | Issue Date: | 2009 | Publisher: | Centro de Matemática da Universidade de Coimbra | Citation: | Pré-Publicações DMUC. 09-20 (2009) | Abstract: | This paper focuses on ophthalmic drug release from a loaded copolymer: the drug is dispersed in the polymeric matrix and entrapped in particles. The copolymer is based in 2-hydroxyethyl methacrylate co-methacrylic acid and silicone is used to prepare the loaded particles. A mathematical model to simulate the drug release is proposed and a qualitative analysis is performed. Experimental results are compared with simulation results. Contact lens made from the presented copolymer are expected to deliver drug at therapeutical levels for a few days. | URI: | https://hdl.handle.net/10316/11167 | Rights: | openAccess |
| Appears in Collections: | FMUC Medicina - Vários FCTUC Eng.Química - Vários FCTUC Matemática - Vários |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Sustained drug released from contact lens.pdf | 3.78 MB | Adobe PDF | View/Open |
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