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https://hdl.handle.net/10316/110856
Título: | Analysis of Nigerians with apparently sporadic Parkinson disease for mutations in LRRK2, PRKN and ATXN3 | Autor: | Okubadejo, Njideka Britton, Angela Crews, Cynthia Akinyemi, Rufus Hardy, John Singleton, Andrew Brás, José |
Data: | 2008 | Editora: | Public Library of Science | Projeto: | Intramural Research Program of the National Institute on Aging, National Institutes of Health, Department of Health and Human Services; Annual Report number Z01-AG000957-05 SFRH/BD/29647/2006 |
Título da revista, periódico, livro ou evento: | PLoS ONE | Volume: | 3 | Número: | 10 | Resumo: | Several genetic variations have been associated with Parkinson disease in different populations over the past few years. Although a considerable number of worldwide populations have been screened for these variants, results from Sub-Saharan populations are very scarce in the literature. In the present report we have screened a cohort of Parkinson disease patients (n = 57) and healthy controls (n = 51) from Nigeria for mutations in the genes PRKN, LRRK2 and ATXN3. No pathogenic mutations were found in any of the genes. Hence, common pathogenic mutations in these genes, observed in several different populations, are not a frequent cause of Parkinson disease in Nigeria. | URI: | https://hdl.handle.net/10316/110856 | ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0003421 | Direitos: | openAccess |
Aparece nas coleções: | I&D CNC - Artigos em Revistas Internacionais |
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Ficheiro | Descrição | Tamanho | Formato | |
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Analysis-of-Nigerians-with-apparently-sporadic-Parkinson-disease-for-mutations-in-LRRK2-PRKN-and-ATXN3PLoS-ONE.pdf | 80.12 kB | Adobe PDF | Ver/Abrir |
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