Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/110856
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Okubadejo, Njideka | - |
dc.contributor.author | Britton, Angela | - |
dc.contributor.author | Crews, Cynthia | - |
dc.contributor.author | Akinyemi, Rufus | - |
dc.contributor.author | Hardy, John | - |
dc.contributor.author | Singleton, Andrew | - |
dc.contributor.author | Brás, José | - |
dc.date.accessioned | 2023-11-24T10:02:30Z | - |
dc.date.available | 2023-11-24T10:02:30Z | - |
dc.date.issued | 2008 | - |
dc.identifier.issn | 1932-6203 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/110856 | - |
dc.description.abstract | Several genetic variations have been associated with Parkinson disease in different populations over the past few years. Although a considerable number of worldwide populations have been screened for these variants, results from Sub-Saharan populations are very scarce in the literature. In the present report we have screened a cohort of Parkinson disease patients (n = 57) and healthy controls (n = 51) from Nigeria for mutations in the genes PRKN, LRRK2 and ATXN3. No pathogenic mutations were found in any of the genes. Hence, common pathogenic mutations in these genes, observed in several different populations, are not a frequent cause of Parkinson disease in Nigeria. | pt |
dc.language.iso | eng | pt |
dc.publisher | Public Library of Science | pt |
dc.relation | Intramural Research Program of the National Institute on Aging, National Institutes of Health, Department of Health and Human Services; Annual Report number Z01-AG000957-05 | pt |
dc.relation | SFRH/BD/29647/2006 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject.mesh | Adult | pt |
dc.subject.mesh | Aged | pt |
dc.subject.mesh | Ataxin-3 | pt |
dc.subject.mesh | Case-Control Studies | pt |
dc.subject.mesh | Cohort Studies | pt |
dc.subject.mesh | DNA Mutational Analysis | pt |
dc.subject.mesh | Female | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Middle Aged | pt |
dc.subject.mesh | Nerve Tissue Proteins | pt |
dc.subject.mesh | Nigeria | pt |
dc.subject.mesh | Nuclear Proteins | pt |
dc.subject.mesh | Parkinson Disease | pt |
dc.subject.mesh | Protein Serine-Threonine Kinases | pt |
dc.subject.mesh | Repressor Proteins | pt |
dc.subject.mesh | Ubiquitin-Protein Ligases | pt |
dc.subject.mesh | Mutation | pt |
dc.title | Analysis of Nigerians with apparently sporadic Parkinson disease for mutations in LRRK2, PRKN and ATXN3 | pt |
dc.type | article | - |
degois.publication.firstPage | e3421 | pt |
degois.publication.issue | 10 | pt |
degois.publication.title | PLoS ONE | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1371/journal.pone.0003421 | pt |
degois.publication.volume | 3 | pt |
dc.date.embargo | 2008-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.fulltext | Com Texto completo | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Analysis-of-Nigerians-with-apparently-sporadic-Parkinson-disease-for-mutations-in-LRRK2-PRKN-and-ATXN3PLoS-ONE.pdf | 80.12 kB | Adobe PDF | View/Open |
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This item is licensed under a Creative Commons License