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Title: | Preventive but not curative efficacy of celecoxib on bladder carcinogenesis in a rat model | Authors: | Sereno, José Parada, Belmiro Reis, Flávio Cunha, Fernanda X Teixeira-Lemos, Edite Garrido, Patrícia Pinto, Rui Rocha-Pereira, Petronila Neto, Paula Ruivo, José da Silva Santos, Paulo Rodrigues dos Nunes, Sara Mota, Alfredo Figueiredo, Arnaldo Teixeira, Frederico |
Issue Date: | 2010 | Publisher: | Hindawi | Serial title, monograph or event: | Mediators of Inflammation | Volume: | 2010 | Abstract: | To evaluate the effect of a cyclooxygenase 2 inhibitor, celecoxib (CEL), on bladder cancer inhibition in a rat model, when used as preventive versus as curative treatment. The study comprised 52 male Wistar rats, divided in 5 groups, during a 20-week protocol: control: vehicle, carcinogen: 0.05% of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN), CEL: 10 mg/kg/day of the selective COX-2 inhibitor Celebrex, preventive CEL (CEL+BBN-P), and curative CEL (BBN+CEL-C) groups. Although tumor growth was markedly inhibited by the preventive application of CEL, it was even aggravated by the curative treatment. The incidence of gross bladder carcinoma was: control 0/8(0%), BBN 13/20(65%), CEL 0/8(0%), CEL+BBN-P 1/8(12.5%), and BBN+CEL-C 6/8(75%). The number and volume of carcinomas were significantly lower in the CEL+BBN-P versus BBN, accompanied by an ample reduction in hyperplasia, dysplasia, and papillary tumors as well as COX-2 immunostaining. In spite of the reduction of tumor volumes in the curative BBN+CEL-C group, tumor malignancy was augmented. An anti-inflammatory and antioxidant profile was encountered only in the group under preventive treatment. In conclusion, preventive, but not curative, celecoxib treatment promoted a striking inhibitory effect on bladder cancer development, reinforcing the potential role of chemopreventive strategies based on cyclooxygenase 2 inhibition. | URI: | https://hdl.handle.net/10316/110204 | ISSN: | 0962-9351 1466-1861 |
DOI: | 10.1155/2010/380937 | Rights: | openAccess |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais I&D IBILI - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
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