Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/110204
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sereno, José | - |
dc.contributor.author | Parada, Belmiro | - |
dc.contributor.author | Reis, Flávio | - |
dc.contributor.author | Cunha, Fernanda X | - |
dc.contributor.author | Teixeira-Lemos, Edite | - |
dc.contributor.author | Garrido, Patrícia | - |
dc.contributor.author | Pinto, Rui | - |
dc.contributor.author | Rocha-Pereira, Petronila | - |
dc.contributor.author | Neto, Paula | - |
dc.contributor.author | Ruivo, José da Silva | - |
dc.contributor.author | Santos, Paulo Rodrigues dos | - |
dc.contributor.author | Nunes, Sara | - |
dc.contributor.author | Mota, Alfredo | - |
dc.contributor.author | Figueiredo, Arnaldo | - |
dc.contributor.author | Teixeira, Frederico | - |
dc.date.accessioned | 2023-11-17T11:09:04Z | - |
dc.date.available | 2023-11-17T11:09:04Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0962-9351 | pt |
dc.identifier.issn | 1466-1861 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/110204 | - |
dc.description.abstract | To evaluate the effect of a cyclooxygenase 2 inhibitor, celecoxib (CEL), on bladder cancer inhibition in a rat model, when used as preventive versus as curative treatment. The study comprised 52 male Wistar rats, divided in 5 groups, during a 20-week protocol: control: vehicle, carcinogen: 0.05% of N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN), CEL: 10 mg/kg/day of the selective COX-2 inhibitor Celebrex, preventive CEL (CEL+BBN-P), and curative CEL (BBN+CEL-C) groups. Although tumor growth was markedly inhibited by the preventive application of CEL, it was even aggravated by the curative treatment. The incidence of gross bladder carcinoma was: control 0/8(0%), BBN 13/20(65%), CEL 0/8(0%), CEL+BBN-P 1/8(12.5%), and BBN+CEL-C 6/8(75%). The number and volume of carcinomas were significantly lower in the CEL+BBN-P versus BBN, accompanied by an ample reduction in hyperplasia, dysplasia, and papillary tumors as well as COX-2 immunostaining. In spite of the reduction of tumor volumes in the curative BBN+CEL-C group, tumor malignancy was augmented. An anti-inflammatory and antioxidant profile was encountered only in the group under preventive treatment. In conclusion, preventive, but not curative, celecoxib treatment promoted a striking inhibitory effect on bladder cancer development, reinforcing the potential role of chemopreventive strategies based on cyclooxygenase 2 inhibition. | pt |
dc.language.iso | eng | pt |
dc.publisher | Hindawi | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject.mesh | Animals | pt |
dc.subject.mesh | Anticarcinogenic Agents | pt |
dc.subject.mesh | Butylhydroxybutylnitrosamine | pt |
dc.subject.mesh | Celecoxib | pt |
dc.subject.mesh | Cyclooxygenase 2 Inhibitors | pt |
dc.subject.mesh | Disease Models, Animal | pt |
dc.subject.mesh | Inflammation Mediators | pt |
dc.subject.mesh | Kidney | pt |
dc.subject.mesh | Liver | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Oxidation-Reduction | pt |
dc.subject.mesh | Pyrazoles | pt |
dc.subject.mesh | Rats | pt |
dc.subject.mesh | Rats, Wistar | pt |
dc.subject.mesh | Sulfonamides | pt |
dc.subject.mesh | Urinary Bladder Neoplasms | pt |
dc.title | Preventive but not curative efficacy of celecoxib on bladder carcinogenesis in a rat model | pt |
dc.type | article | - |
degois.publication.firstPage | 380937 | pt |
degois.publication.lastPage | 11 | pt |
degois.publication.title | Mediators of Inflammation | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1155/2010/380937 | pt |
degois.publication.volume | 2010 | pt |
dc.date.embargo | 2010-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
item.openairetype | article | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.researchunit | ICBR Coimbra Institute for Clinical and Biomedical Research | - |
crisitem.author.researchunit | CNC - Center for Neuroscience and Cell Biology | - |
crisitem.author.parentresearchunit | Faculty of Medicine | - |
crisitem.author.orcid | 0000-0003-3401-9554 | - |
crisitem.author.orcid | 0000-0002-6346-8319 | - |
crisitem.author.orcid | 0000-0002-7157-0081 | - |
crisitem.author.orcid | 0000-0002-2601-0923 | - |
Appears in Collections: | I&D CNC - Artigos em Revistas Internacionais I&D IBILI - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Preventive-but-Not-curative-efficacy-of-celecoxib-on-bladder-carcinogenesis-in-a-rat-modelMediators-of-Inflammation.pdf | 7.72 MB | Adobe PDF | View/Open |
Page view(s)
86
checked on Jul 10, 2024
Download(s)
14
checked on Jul 10, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License