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Título: | Compatibility study of paracetamol, chlorpheniramine maleate and phenylephrine hydrochloride in physical mixtures | Autor: | de Oliveira, G. G. G. Feitosa, A. Loureiro, K. Fernandes, A. R. Souto, E. B. Severino, P. |
Palavras-chave: | Chlorpheniramine maleate and phenylephrine hydrochloride; Differential Scanning Calorimetry (DSC); Paracetamol; Thermogravimetric analysis (TGA) | Data: | Jan-2017 | Editora: | Elsevier | Projeto: | The authors wish to acknowledge the sponsorship of the FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo), CAPES (Coordenação Aperfeiçoamento de Pessoal de Nivel Superior) and CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico), Process #443238/2014-6, #470388/2014-5. This work was also financed through the project UID/QUI/50006/2013, receiving support from the Portuguese Science and Technology Foundation, Ministry of Science and Education (FCT/MEC) through national funds, and co-financed by FEDER, under the Partnership Agreement PT2020. | Título da revista, periódico, livro ou evento: | Saudi Pharmaceutical Journal | Volume: | 25 | Número: | 1 | Resumo: | Paracetamol (PAR), phenylephrine hydrochloride (PHE) and chlorpheniramine maleate (CPM) are commonly used in clinical practice as antipyretic and analgesic drugs to ameliorate pain and fever in cold and flu conditions. The present work describes the use of thermal analysis for the characterization of the physicochemical compatibility between drugs and excipients during the development of solid dosage forms. Thermogravimetric analysis (TGA) and Differential Scanning Calorimetry (DSC) were used to study the thermal stability of the drug and of the physical mixture (drug/excipients) in solid binary mixtures (1:1). DSC thermograms demonstrated reproducible melting event of the prepared physical mixture. Starch, mannitol, lactose and magnesium stearate influence thermal parameters. Information recorded from the derivative thermogravimetric (DTG) and TGA curves demonstrated the decomposition of drugs in well-defined thermal events, translating the suitability of these techniques for the characterization of the drug/excipients interactions. | URI: | https://hdl.handle.net/10316/108364 | ISSN: | 1319-0164 | DOI: | 10.1016/j.jsps.2016.05.001 | Direitos: | openAccess |
Aparece nas coleções: | FFUC- Artigos em Revistas Internacionais |
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Ficheiro | Descrição | Tamanho | Formato | |
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Compatibility study of paracetamol,.pdf | 6.05 MB | Adobe PDF | Ver/Abrir |
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