Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/108364
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dc.contributor.authorde Oliveira, G. G. G.-
dc.contributor.authorFeitosa, A.-
dc.contributor.authorLoureiro, K.-
dc.contributor.authorFernandes, A. R.-
dc.contributor.authorSouto, E. B.-
dc.contributor.authorSeverino, P.-
dc.date.accessioned2023-08-25T13:00:14Z-
dc.date.available2023-08-25T13:00:14Z-
dc.date.issued2017-01-
dc.identifier.issn1319-0164pt
dc.identifier.urihttps://hdl.handle.net/10316/108364-
dc.description.abstractParacetamol (PAR), phenylephrine hydrochloride (PHE) and chlorpheniramine maleate (CPM) are commonly used in clinical practice as antipyretic and analgesic drugs to ameliorate pain and fever in cold and flu conditions. The present work describes the use of thermal analysis for the characterization of the physicochemical compatibility between drugs and excipients during the development of solid dosage forms. Thermogravimetric analysis (TGA) and Differential Scanning Calorimetry (DSC) were used to study the thermal stability of the drug and of the physical mixture (drug/excipients) in solid binary mixtures (1:1). DSC thermograms demonstrated reproducible melting event of the prepared physical mixture. Starch, mannitol, lactose and magnesium stearate influence thermal parameters. Information recorded from the derivative thermogravimetric (DTG) and TGA curves demonstrated the decomposition of drugs in well-defined thermal events, translating the suitability of these techniques for the characterization of the drug/excipients interactions.pt
dc.language.isoengpt
dc.publisherElsevierpt
dc.relationThe authors wish to acknowledge the sponsorship of the FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo), CAPES (Coordenação Aperfeiçoamento de Pessoal de Nivel Superior) and CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico), Process #443238/2014-6, #470388/2014-5. This work was also financed through the project UID/QUI/50006/2013, receiving support from the Portuguese Science and Technology Foundation, Ministry of Science and Education (FCT/MEC) through national funds, and co-financed by FEDER, under the Partnership Agreement PT2020.pt
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt
dc.subjectChlorpheniramine maleate and phenylephrine hydrochloridept
dc.subjectDifferential Scanning Calorimetry (DSC)pt
dc.subjectParacetamolpt
dc.subjectThermogravimetric analysis (TGA)pt
dc.titleCompatibility study of paracetamol, chlorpheniramine maleate and phenylephrine hydrochloride in physical mixturespt
dc.typearticle-
degois.publication.firstPage99pt
degois.publication.lastPage103pt
degois.publication.issue1pt
degois.publication.titleSaudi Pharmaceutical Journalpt
dc.peerreviewedyespt
dc.identifier.doi10.1016/j.jsps.2016.05.001pt
degois.publication.volume25pt
dc.date.embargo2017-01-01*
uc.date.periodoEmbargo0pt
item.grantfulltextopen-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.openairetypearticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextCom Texto completo-
crisitem.author.orcid0000-0002-9737-6017-
Appears in Collections:FFUC- Artigos em Revistas Internacionais
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