Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/108314
Título: | Properties of halogenated and sulfonated porphyrins relevant for the selection of photosensitizers in anticancer and antimicrobial therapies | Autor: | Pucelik, Barbara Paczyński, Robert Dubin, Grzegorz Pereira, Mariette M. Arnaut, Luís G. Dąbrowski, Janusz M. |
Data: | 2017 | Editora: | Public Library of Science | Projeto: | National Science Center (NCN), Poland within the Sonata Bis grant no 0085/IP3/2015/73 given to | Título da revista, periódico, livro ou evento: | PLoS ONE | Volume: | 12 | Número: | 10 | Resumo: | The impact of substituents on the photochemical and biological properties of tetraphenylporphyrin-based photosensitizers for photodynamic therapy of cancer (PDT) as well as photodynamic inactivation of microorganisms (PDI) was examined. Spectroscopic and physicochemical properties were related with therapeutic efficacy in PDT of cancer and PDI of microbial cells in vitro. Less polar halogenated, sulfonamide porphyrins were most readily taken up by cells compared to hydrophilic and anionic porphyrins. The uptake and PDT of a hydrophilic porphyrin was significantly enhanced with incorporation in polymeric micelles (Pluronic L121). Photodynamic inactivation studies were performed against Gram-positive (S. aureus, E. faecalis), Gram-negative bacteria (E. coli, P. aeruginosa, S. marcescens) and fungal yeast (C. albicans). We observed a 6 logs reduction of S. aureus after irradiation (10 J/cm2) in the presence of 20 μM of hydrophilic porphyrin, but this was not improved with incorporation in Pluronic L121. A 2-3 logs reduction was obtained for E. coli using similar doses, and a decrease of 3-4 logs was achieved for C. albicans. Rational substitution of tetraphenylporphyrins improves their photodynamic properties and informs on strategies to obtain photosensitizers for efficient PDT and PDI. However, the design of the photosensitizers must be accompanied by the development of tailored drug formulations. | URI: | https://hdl.handle.net/10316/108314 | ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0185984 | Direitos: | openAccess |
Aparece nas coleções: | FCTUC Química - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
---|---|---|---|---|
Properties-of-halogenated-and-sulfonated-porphyrins-relevant-for-the-selection-of-photosensitizers-in-anticancer-and-antimicrobial-therapiesPLoS-ONE.pdf | 2.73 MB | Adobe PDF | Ver/Abrir |
Visualizações de página
31
Visto em 8/mai/2024
Downloads
18
Visto em 8/mai/2024
Google ScholarTM
Verificar
Altmetric
Altmetric
Este registo está protegido por Licença Creative Commons