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https://hdl.handle.net/10316/108062| Título: | Generation and characterization of a human iPS cell line from a patient-related control to study disease mechanisms associated with DAND5 p.R152H alteration | Autor: | Pars, Selin Cristo, Fernando Inácio, José M. Rosas, Graça Carreira, Isabel Marques Melo, Joana Barbosa Mendes, Patrícia Martins, Duarte Saraiva Almeida, Luís Pereira de Maio, José Anjos, Rui Belo, José A. |
Data: | Mai-2018 | Editora: | Elsevier | Projeto: | FCT - (PTDC/BIM-MED/3363/2014) iNOVA4Health - UID/ Multi/04462/2013, a program financially supported by Fundação para a Ciência e Tecnologia/Ministério da Educação e Ciência, through national funds and co-funded by FEDER under the PT2020 Partnership Agreement is acknowledged |
Título da revista, periódico, livro ou evento: | Stem Cell Research | Volume: | 29 | Resumo: | A DAND5-control human iPSC line was generated from the urinary cells of a phenotypically normal donor. Exfoliated renal epithelial (RE) cells were collected and reprogrammed into iPSCs using Sendai virus reprogramming system. The pluripotency, in vitro differentiation potential, karyotype stability, and the transgene-free status of generated iPSC line were analyzed and confirmed. This cell line can be exploited as a control iPSC line to better understand the mechanisms involved in DAND5-associated cardiac disease. | URI: | https://hdl.handle.net/10316/108062 | ISSN: | 18735061 | DOI: | 10.1016/j.scr.2018.04.015 | Direitos: | openAccess |
| Aparece nas coleções: | I&D CIBIT - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| Generation and characterization of a human iPS cell line from a patient-related control to study disease mechanisms associated with DAND5 p.R152H alteration.pdf | 2.95 MB | Adobe PDF | Ver/Abrir |
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