Please use this identifier to cite or link to this item: https://hdl.handle.net/10316/108042
DC FieldValueLanguage
dc.contributor.authorRodrigues, Carlos F. D.-
dc.contributor.authorSerrano, Eurico-
dc.contributor.authorPatrício, Maria I.-
dc.contributor.authorVal, Mariana-
dc.contributor.authorAlbuquerque, Patrícia-
dc.contributor.authorFonseca, João-
dc.contributor.authorGomes, Célia M. F.-
dc.contributor.authorAbrunhosa, Antero-
dc.contributor.authorPaiva, Artur-
dc.contributor.authorCarvalho, Lina-
dc.contributor.authorBotelho, Maria F.-
dc.contributor.authorAlmeida, Luís-
dc.contributor.authorCarreira, Isabel M.-
dc.contributor.authorAlpoim, Maria Carmen-
dc.date.accessioned2023-08-07T11:40:25Z-
dc.date.available2023-08-07T11:40:25Z-
dc.date.issued2018-08-01-
dc.identifier.issn2045-2322pt
dc.identifier.urihttps://hdl.handle.net/10316/108042-
dc.description.abstractCancer stem cells (CSCs) are a small population of resistant cells inhabiting the tumors. Although comprising only nearly 3% of the tumor mass, these cells were demonstrated to orchestrate tumorigenesis and differentiation, underlie tumors' heterogeneity and mediate therapy resistance and tumor relapse. Here we show that CSCs may be formed by dedifferentiation of terminally differentiated tumor cells under stress conditions. Using a elegant co-culture cellular system, we were able to prove that nutrients and oxygen deprivation activated non-malignant stromal fibroblasts, which in turn established with tumor cells a paracrine loop mediated by Interleukine-6 (IL-6), Activin-A and Granulocyte colony-stimulating factor (G-CSF), that drove subsequent tumor formation and cellular dedifferentiation. However, by scavenging these cytokines from the media and/or blocking exosomes' mediated communication it was possible to abrogate dedifferentiation thus turning these mechanisms into potential therapeutic targets against cancer progression.pt
dc.language.isoengpt
dc.publisherSpringer Naturept
dc.rightsopenAccesspt
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt
dc.subject.meshActivinspt
dc.subject.meshAnimalspt
dc.subject.meshCarcinogenesispt
dc.subject.meshCell Differentiationpt
dc.subject.meshCell Line, Tumorpt
dc.subject.meshCoculture Techniquespt
dc.subject.meshGranulocyte Colony-Stimulating Factorpt
dc.subject.meshHumanspt
dc.subject.meshInterleukin-6pt
dc.subject.meshMice, Inbred BALB Cpt
dc.subject.meshMice, SCIDpt
dc.subject.meshNeoplasms, Experimentalpt
dc.subject.meshNeoplastic Stem Cellspt
dc.subject.meshStromal Cellspt
dc.titleStroma-derived IL-6, G-CSF and Activin-A mediated dedifferentiation of lung carcinoma cells into cancer stem cellspt
dc.typearticle-
degois.publication.firstPage11573pt
degois.publication.issue1pt
degois.publication.titleScientific Reportspt
dc.peerreviewedyespt
dc.identifier.doi10.1038/s41598-018-29947-wpt
degois.publication.volume8pt
dc.date.embargo2018-08-01*
uc.date.periodoEmbargo0pt
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypearticle-
item.cerifentitytypePublications-
item.grantfulltextopen-
item.fulltextCom Texto completo-
item.languageiso639-1en-
crisitem.author.researchunitICNAS - Institute for Nuclear Sciences Applied to Health-
crisitem.author.researchunitiNOVA4Health - Programme in Translational Medicine (iBET, CEDOC/FCM, IPOLFG and ITQB)-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.researchunitCIBB - Center for Innovative Biomedicine and Biotechnology-
crisitem.author.researchunitCNC - Center for Neuroscience and Cell Biology-
crisitem.author.orcid0000-0003-1685-9883-
crisitem.author.orcid0000-0002-7497-4129-
crisitem.author.orcid0000-0002-4145-854X-
crisitem.author.orcid0000-0002-6562-5859-
crisitem.author.orcid0000-0001-8349-4488-
crisitem.author.orcid0000-0001-7202-1650-
crisitem.author.orcid0000-0001-5831-3307-
crisitem.author.orcid0000-0001-6842-1707-
crisitem.author.orcid0000-0001-7273-9371-
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais
FFUC- Artigos em Revistas Internacionais
FMUC Medicina - Artigos em Revistas Internacionais
I&D CNC - Artigos em Revistas Internacionais
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