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https://hdl.handle.net/10316/108042
Título: | Stroma-derived IL-6, G-CSF and Activin-A mediated dedifferentiation of lung carcinoma cells into cancer stem cells | Autor: | Rodrigues, Carlos F. D. Serrano, Eurico Patrício, Maria I. Val, Mariana Albuquerque, Patrícia Fonseca, João Gomes, Célia M. F. Abrunhosa, Antero Paiva, Artur Carvalho, Lina Botelho, Maria F. Almeida, Luís Carreira, Isabel M. Alpoim, Maria Carmen |
Data: | 1-Ago-2018 | Editora: | Springer Nature | Título da revista, periódico, livro ou evento: | Scientific Reports | Volume: | 8 | Número: | 1 | Resumo: | Cancer stem cells (CSCs) are a small population of resistant cells inhabiting the tumors. Although comprising only nearly 3% of the tumor mass, these cells were demonstrated to orchestrate tumorigenesis and differentiation, underlie tumors' heterogeneity and mediate therapy resistance and tumor relapse. Here we show that CSCs may be formed by dedifferentiation of terminally differentiated tumor cells under stress conditions. Using a elegant co-culture cellular system, we were able to prove that nutrients and oxygen deprivation activated non-malignant stromal fibroblasts, which in turn established with tumor cells a paracrine loop mediated by Interleukine-6 (IL-6), Activin-A and Granulocyte colony-stimulating factor (G-CSF), that drove subsequent tumor formation and cellular dedifferentiation. However, by scavenging these cytokines from the media and/or blocking exosomes' mediated communication it was possible to abrogate dedifferentiation thus turning these mechanisms into potential therapeutic targets against cancer progression. | URI: | https://hdl.handle.net/10316/108042 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-018-29947-w | Direitos: | openAccess |
Aparece nas coleções: | FCTUC Ciências da Vida - Artigos em Revistas Internacionais FFUC- Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais I&D CNC - Artigos em Revistas Internacionais |
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Ficheiro | Descrição | Tamanho | Formato | |
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Stromaderived-IL6-GCSF-and-ActivinA-mediated-dedifferentiation-of-lung-carcinoma-cells-into-cancer-stem-cellsScientific-Reports.pdf | 5.74 MB | Adobe PDF | Ver/Abrir |
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