Utilize este identificador para referenciar este registo:
https://hdl.handle.net/10316/107636
Título: | Vascular Oxidative Stress: Impact and Therapeutic Approaches | Autor: | Sena, Cristina M. Leandro, Adriana Azul, Lara Seiça, Raquel Perry, George |
Palavras-chave: | oxidative stress; vasculature; reactive oxygen species; therapies; antioxidants | Data: | 2018 | Editora: | Frontiers Media S.A. | Projeto: | PTDC/BIM-MET/4447/2014 POCI-01-0145-FEDER-016784 |
Título da revista, periódico, livro ou evento: | Frontiers in Physiology | Volume: | 9 | Resumo: | Oxidative stress has been defined as an imbalance between oxidants and antioxidants and more recently as a disruption of redox signaling and control. It is generally accepted that oxidative stress can lead to cell and tissue injury having a fundamental role in vascular dysfunction. Physiologically, reactive oxygen species (ROS) control vascular function by modulating various redox-sensitive signaling pathways. In vascular disorders, oxidative stress instigates endothelial dysfunction and inflammation, affecting several cells in the vascular wall. Vascular ROS are derived from multiple sources herein discussed, which are prime targets for therapeutic development. This review focuses on oxidative stress in vascular physiopathology and highlights different strategies to inhibit ROS production. | URI: | https://hdl.handle.net/10316/107636 | ISSN: | 1664-042X | DOI: | 10.3389/fphys.2018.01668 | Direitos: | openAccess |
Aparece nas coleções: | I&D ICBR - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Vascular oxidative stress Impact and therapeutic approaches.pdf | 4.13 MB | Adobe PDF | Ver/Abrir |
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