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https://hdl.handle.net/10316/107110
Title: | The cerebellum is causally involved in episodic memory under aging | Authors: | Almeida, Armando Martins, Ana R. Amaral, Lénia Valério, Daniela Bukhari, Qasim Schu, Guilherme Nogueira, Joana Spínola, Mónica Soleimani, Ghazaleh Fernandes, Filipe Silva, Ana R. Fregni, Felipe Simis, Marcel Simões, Mário Peres, André |
Keywords: | Cerebellum; Episodic memory decline; Neurostimulation | Issue Date: | 7-Feb-2023 | Publisher: | Springer Nature | Project: | info:eu-repo/grantAgreement/EC/H2020/802553/EU/Contentotopic mapping: the topographical organization of object knowledge in the brain info:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH/BD/136029/2018/PT/The impact of Cognitive Reserve on healthy aging and dementia info:eu-repo/grantAgreement/FCT/POR_CENTRO/SFRH/BD/137737/2018/PT/Local or Global The effects of transcranial direct current stimulation tDCS in brain processing. info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC/PSI-GER/30757/2017/PT/Seeing with your ears: how deafness-induced neuroplasticity impacts neural processing and auditory restoration efforts 2020.00524.CEECIND BIAL foundation grant #495/14 FAPESP-SPEC grant 17/12943-8 |
Serial title, monograph or event: | GeoScience | Abstract: | Episodic memory decline is a major signature of both normal and pathological aging. Many neural regions have been implicated in the processes subserving both episodic memory and typical aging decline. Here, we demonstrate that the cerebellum is causally involved episodic memory under aging. We show that a 12-day neurostimulation program delivered to the right cerebellum led to improvements in episodic memory performance under healthy aging that long outlast the stimulation period - healthy elderly individuals show episodic memory improvement both immediately after the intervention program and in a 4-month follow-up. These results demonstrate the causal relevance of the cerebellum in processes associated with long-term episodic memory, potentially highlighting its role in regulating and maintaining cognitive processing. Moreover, they point to the importance of non-pharmacological interventions that prevent or diminish cognitive decline in healthy aging. | URI: | https://hdl.handle.net/10316/107110 | ISSN: | 2509-2715 2509-2723 |
DOI: | 10.1007/s11357-023-00738-0 | Rights: | openAccess |
Appears in Collections: | I&D CINEICC - Artigos em Revistas Internacionais |
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