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https://hdl.handle.net/10316/106121
Título: | Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies | Autor: | Jorge, Ludmilla R. Harada, Liliam K. Silva, Erica C. Campos, Welida F. Moreli, Fernanda C. Shimamoto, Gustavo Pereira, Jorge F. B. Oliveira, José M Tubino, Matthieu Vila, Marta M. D. C. Balcão, Victor M. |
Palavras-chave: | human insulin; ionic liquids; choline geranate; choline oleate; transdermal permeation; chemical and biological characterization | Data: | 2020 | Editora: | Frontiers Media S.A. | Projeto: | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, São Paulo, Brazil) [FAPESP Refs. No. 2016/08884-3 (Project PneumoPhageColor), 2016/12234-4 (Project TransAppIL), and 2018/05522-9 (Project PsaPhageKill, in the form of a BPE fellowship granted to VB)] CNPq, National Council for Scientific and Technological Development Brazil, in the form of Research Productivity (PQ) fellowships granted to VB (Refs. No. 306113/2014-7 and 308208/2017-0) |
Título da revista, periódico, livro ou evento: | Frontiers in Pharmacology | Volume: | 11 | Resumo: | In this research project, synthesis and characterization of ionic liquids and their subsequent utilization as facilitators of transdermal delivery of human insulin was pursued. Choline geranate and choline oleate ionic liquids (and their deep eutectic solvents) were produced and characterized by nuclear magnetic resonance (1H NMR), water content, oxidative stability, cytotoxicity and genotoxicity assays, and ability to promote transdermal protein permeation. The results gathered clearly suggest that all ionic liquids were able to promote/facilitate transdermal permeation of insulin, although to various extents. In particular, choline geranate 1:2 combined with its virtually nil cyto- and geno-toxicity was chosen to be incorporated in a biopolymeric formulation making it a suitable facilitator aiming at transdermal delivery of insulin. | URI: | https://hdl.handle.net/10316/106121 | ISSN: | 1663-9812 | DOI: | 10.3389/fphar.2020.00243 | Direitos: | openAccess |
Aparece nas coleções: | I&D CERES - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids In vitro Studies.pdf | 9.9 MB | Adobe PDF | Ver/Abrir |
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