Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/106121
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jorge, Ludmilla R. | - |
dc.contributor.author | Harada, Liliam K. | - |
dc.contributor.author | Silva, Erica C. | - |
dc.contributor.author | Campos, Welida F. | - |
dc.contributor.author | Moreli, Fernanda C. | - |
dc.contributor.author | Shimamoto, Gustavo | - |
dc.contributor.author | Pereira, Jorge F. B. | - |
dc.contributor.author | Oliveira, José M | - |
dc.contributor.author | Tubino, Matthieu | - |
dc.contributor.author | Vila, Marta M. D. C. | - |
dc.contributor.author | Balcão, Victor M. | - |
dc.date.accessioned | 2023-03-21T11:58:42Z | - |
dc.date.available | 2023-03-21T11:58:42Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1663-9812 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/106121 | - |
dc.description.abstract | In this research project, synthesis and characterization of ionic liquids and their subsequent utilization as facilitators of transdermal delivery of human insulin was pursued. Choline geranate and choline oleate ionic liquids (and their deep eutectic solvents) were produced and characterized by nuclear magnetic resonance (1H NMR), water content, oxidative stability, cytotoxicity and genotoxicity assays, and ability to promote transdermal protein permeation. The results gathered clearly suggest that all ionic liquids were able to promote/facilitate transdermal permeation of insulin, although to various extents. In particular, choline geranate 1:2 combined with its virtually nil cyto- and geno-toxicity was chosen to be incorporated in a biopolymeric formulation making it a suitable facilitator aiming at transdermal delivery of insulin. | pt |
dc.language.iso | eng | pt |
dc.publisher | Frontiers Media S.A. | pt |
dc.relation | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP, São Paulo, Brazil) [FAPESP Refs. No. 2016/08884-3 (Project PneumoPhageColor), 2016/12234-4 (Project TransAppIL), and 2018/05522-9 (Project PsaPhageKill, in the form of a BPE fellowship granted to VB)] | pt |
dc.relation | CNPq, National Council for Scientific and Technological Development Brazil, in the form of Research Productivity (PQ) fellowships granted to VB (Refs. No. 306113/2014-7 and 308208/2017-0) | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | human insulin | pt |
dc.subject | ionic liquids | pt |
dc.subject | choline geranate | pt |
dc.subject | choline oleate | pt |
dc.subject | transdermal permeation | pt |
dc.subject | chemical and biological characterization | pt |
dc.title | Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids: In vitro Studies | pt |
dc.type | article | - |
degois.publication.firstPage | 243 | pt |
degois.publication.title | Frontiers in Pharmacology | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3389/fphar.2020.00243 | pt |
degois.publication.volume | 11 | pt |
dc.date.embargo | 2020-01-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | article | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
crisitem.author.orcid | 0000-0001-5959-0015 | - |
Appears in Collections: | I&D CERES - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
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Non-invasive Transdermal Delivery of Human Insulin Using Ionic Liquids In vitro Studies.pdf | 9.9 MB | Adobe PDF | View/Open |
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This item is licensed under a Creative Commons License