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https://hdl.handle.net/10316/105857
Título: | Urine-Derived Stem Cells: Applications in Regenerative and Predictive Medicine | Autor: | Bento, Guida Shafigullina, Aygul K. Rizvanov, Albert A. Sardão, Vilma A. Macedo, Maria Paula Oliveira, Paulo J. |
Palavras-chave: | urine-derived stem cells; personalized medicine; regenerative medicine; induced-pluripotent stem cells | Data: | 28-Fev-2020 | Editora: | MDPI | Projeto: | PTDC/BTM-SAL/29297/2017 POCI-01-0145-FEDER-029297 PTDC/MED-FAR/29391/2017 POCI-01-0145-FEDER-029391 IF/01182/2015 UIDB/04539/2020 iNOVA4Health-UID/Multi/04462/2013 Ph.D. fellowship PD/BD/114119/2015 subsidy allocated to Kazan Federal University for the state assignment in the sphere of scientific activities Kazan Federal University was supported by the Russian Government Program of Competitive Growth |
Título da revista, periódico, livro ou evento: | Cells | Volume: | 9 | Número: | 3 | Resumo: | Despite being a biological waste, human urine contains a small population of cells with self-renewal capacity and differentiation potential into several cell types. Being derived from the convoluted tubules of nephron, renal pelvis, ureters, bladder and urethra, urine-derived stem cells (UDSC) have a similar phenotype to mesenchymal stroma cells (MSC) and can be reprogrammed into iPSC (induced pluripotent stem cells). Having simple, safer, low-cost and noninvasive collection procedures, the interest in UDSC has been growing in the last decade. With great potential in regenerative medicine applications, UDSC can also be used as biological models for pharmacology and toxicology tests. This review describes UDSC biological characteristics and differentiation potential and their possible use, including the potential of UDSC-derived iPSC to be used in drug discovery and toxicology, as well as in regenerative medicine. Being a new cellular platform amenable to noninvasive collection for disease stratification and personalized therapy could be a future application for UDSC. | URI: | https://hdl.handle.net/10316/105857 | ISSN: | 2073-4409 | DOI: | 10.3390/cells9030573 | Direitos: | openAccess |
Aparece nas coleções: | I&D CNC - Artigos em Revistas Internacionais |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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UrineDerived-Stem-Cells-Applications-in-Regenerative-and-Predictive-MedicineCells.pdf | 1.25 MB | Adobe PDF | Ver/Abrir |
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