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https://hdl.handle.net/10316/105455
Title: | Vitrectomized versus non-vitrectomized eyes in diabetic macular edema response to ranibizumab-retinal layers thickness as prognostic biomarkers | Authors: | Pessoa, Bernardete Leite, João Heitor, João Coelho, João Monteiro, Sérgio Coelho, Constança Figueira, João Meireles, Angelina Melo-Beirão, João Nuno |
Issue Date: | 29-Nov-2021 | Publisher: | Springer Nature | Serial title, monograph or event: | Scientific Reports | Volume: | 11 | Issue: | 1 | Abstract: | To evaluate the role of the vitreous in the management of diabetic macular edema with ranibizumab intravitreal injections in a pro re nata regimen. Prospective study of 50 consecutive eyes with diabetic macular edema treated with ranibizumab and 12 months of follow-up. Primary endpoint: to assess differences between non-vitrectomized and vitrectomized eyes in the number injections needed to control the edema. Secondary endpoints: comparison of groups regarding best corrected visual acuity, central foveal thickness and thickness of seven retinal layers. 46 eyes from 38 patients, 10 vitrectomized and 36 non-vitrectomized, completed the follow-up. At month 12, the two groups achieved an equivalent anatomical outcome and needed a similar number of ranibizumab intravitreal injections. In vitrectomized eyes final visual acuity was worse when baseline retinal nerve fiber layers in the central foveal subfield were thicker, showing a strong correlation (r = - 0.942, p < 0.001). A similar, albeit moderate correlation was observed in non-vitrectomized eyes (r = - 0.504, p = 0.002). A decrease of retinal nerve fiber layers inner ring thickness was correlated with a better final visual acuity only in vitrectomized eyes (r = 0.734, p = 0.016). The effect of diabetic macular edema seems to be worse in vitrectomized eyes, with a thinner inner retina reservoir.Clinicaltrials.govNCT04387604. | URI: | https://hdl.handle.net/10316/105455 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-021-02532-4 | Rights: | openAccess |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais |
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Vitrectomized-versus-nonvitrectomized-eyes-in-diabetic-macular-edema-response-to-ranibizumabretinal-layers-thickness-as-prognostic-biomarkersScientific-Reports.pdf | 1.47 MB | Adobe PDF | View/Open |
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