Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/105455
DC Field | Value | Language |
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dc.contributor.author | Pessoa, Bernardete | - |
dc.contributor.author | Leite, João | - |
dc.contributor.author | Heitor, João | - |
dc.contributor.author | Coelho, João | - |
dc.contributor.author | Monteiro, Sérgio | - |
dc.contributor.author | Coelho, Constança | - |
dc.contributor.author | Figueira, João | - |
dc.contributor.author | Meireles, Angelina | - |
dc.contributor.author | Melo-Beirão, João Nuno | - |
dc.date.accessioned | 2023-03-01T09:46:47Z | - |
dc.date.available | 2023-03-01T09:46:47Z | - |
dc.date.issued | 2021-11-29 | - |
dc.identifier.issn | 2045-2322 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/105455 | - |
dc.description.abstract | To evaluate the role of the vitreous in the management of diabetic macular edema with ranibizumab intravitreal injections in a pro re nata regimen. Prospective study of 50 consecutive eyes with diabetic macular edema treated with ranibizumab and 12 months of follow-up. Primary endpoint: to assess differences between non-vitrectomized and vitrectomized eyes in the number injections needed to control the edema. Secondary endpoints: comparison of groups regarding best corrected visual acuity, central foveal thickness and thickness of seven retinal layers. 46 eyes from 38 patients, 10 vitrectomized and 36 non-vitrectomized, completed the follow-up. At month 12, the two groups achieved an equivalent anatomical outcome and needed a similar number of ranibizumab intravitreal injections. In vitrectomized eyes final visual acuity was worse when baseline retinal nerve fiber layers in the central foveal subfield were thicker, showing a strong correlation (r = - 0.942, p < 0.001). A similar, albeit moderate correlation was observed in non-vitrectomized eyes (r = - 0.504, p = 0.002). A decrease of retinal nerve fiber layers inner ring thickness was correlated with a better final visual acuity only in vitrectomized eyes (r = 0.734, p = 0.016). The effect of diabetic macular edema seems to be worse in vitrectomized eyes, with a thinner inner retina reservoir.Clinicaltrials.govNCT04387604. | pt |
dc.language.iso | eng | pt |
dc.publisher | Springer Nature | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject.mesh | Aged | pt |
dc.subject.mesh | Angiogenesis Inhibitors | pt |
dc.subject.mesh | Diabetes Complications | pt |
dc.subject.mesh | Female | pt |
dc.subject.mesh | Fovea Centralis | pt |
dc.subject.mesh | Humans | pt |
dc.subject.mesh | Intravitreal Injections | pt |
dc.subject.mesh | Laser Therapy | pt |
dc.subject.mesh | Lasers | pt |
dc.subject.mesh | Macular Edema | pt |
dc.subject.mesh | Male | pt |
dc.subject.mesh | Middle Aged | pt |
dc.subject.mesh | Prospective Studies | pt |
dc.subject.mesh | Ranibizumab | pt |
dc.subject.mesh | Retina | pt |
dc.subject.mesh | Visual Acuity | pt |
dc.subject.mesh | Vitrectomy | pt |
dc.title | Vitrectomized versus non-vitrectomized eyes in diabetic macular edema response to ranibizumab-retinal layers thickness as prognostic biomarkers | pt |
dc.type | article | - |
degois.publication.firstPage | 23055 | pt |
degois.publication.issue | 1 | pt |
degois.publication.title | Scientific Reports | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.1038/s41598-021-02532-4 | pt |
degois.publication.volume | 11 | pt |
dc.date.embargo | 2021-11-29 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.orcid | 0000-0002-3511-1515 | - |
Appears in Collections: | FMUC Medicina - Artigos em Revistas Internacionais I&D ICBR - Artigos em Revistas Internacionais |
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File | Description | Size | Format | |
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Vitrectomized-versus-nonvitrectomized-eyes-in-diabetic-macular-edema-response-to-ranibizumabretinal-layers-thickness-as-prognostic-biomarkersScientific-Reports.pdf | 1.47 MB | Adobe PDF | View/Open |
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