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https://hdl.handle.net/10316/105414
Título: | Dependence of Viscosity and Diffusion on β-Cyclodextrin and Chloroquine Diphosphate Interactions | Autor: | Musilová, Lenka Mráček, Aleš Azevedo, Eduarda F. G. Rodrigo, M. Melia Valente, Artur J. M. Esteso, Miguel Á. Ribeiro, Ana C. F. |
Palavras-chave: | chloroquine diphosphate; diffusion; drugs; solutions; transport properties | Data: | 2021 | Editora: | MDPI | Projeto: | UID/QUI/UI0313/2019 Ministry of Education, Youth and Sports of the Czech Republic DKRVO (RP/CPS/2020/003) University of Alcalá (Spain) (Mobility Grants for Researchers-2021) |
Título da revista, periódico, livro ou evento: | Processes | Volume: | 9 | Número: | 8 | Resumo: | Mutual diffusion coefficients of chloroquine diphosphate (CDP) in aqueous solutions both without and with b-cyclodextrin (b-CD) weremeasured at concentrations from(0.0000 to 0.0100)mol dm3 and 298.15 K, using the Taylor dispersion technique. Ternary mutual diffusion coefficients (Dik) measured by the same technique are reported for aqueous CDP + b-CD solutions at 298.15 K. The presence of b CD led to relevant changes in the diffusion process, as showed by nonzero values of the cross-diffusion coefficients, D12 and D21. b-CD concentration gradients produced significant co-current coupled flows of CDP. In addition, the effects of b-CD on the transport of CDP are assessed by comparing the binary diffusion coefficient of aqueous CDP solutions with the main diffusion coefficient (D11) measured for ternary {CDP(1) + b-CD(2)} solutions. These observations are supported by viscosity analysis. All data allow to have a better interpretation on the effect of cyclodextrin on the transport behavior of CDP. | URI: | https://hdl.handle.net/10316/105414 | ISSN: | 2227-9717 | DOI: | 10.3390/pr9081433 | Direitos: | openAccess |
Aparece nas coleções: | I&D CQC - Artigos em Revistas Internacionais |
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Dependence-of-viscosity-and-diffusion-on-cyclodextrin-and-chloroquine-diphosphate-interactionsProcesses.pdf | 517.86 kB | Adobe PDF | Ver/Abrir |
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