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https://hdl.handle.net/10316/105259
Título: | Polysaccharide Structures and Their Hypocholesterolemic Potential | Autor: | Silva, Inês M. V. Machado, Fernanda Moreno, Maria João Nunes, Cláudia Coimbra, Manuel A. Coreta-Gomes, Filipe |
Palavras-chave: | polysaccharides; chitosan; β-glucans; cholesterol homeostasis; viscosity; bile salt sequestration; microbiota; hypocholesterolemic ingredients;; fiber | Data: | 28-Jul-2021 | Editora: | MDPI | Projeto: | UID/QUI/00062/2019 UIDB/50006/2020 UIDB/50011/2020 UIDP/50011/2020 UIDB/00313/2020 UIDP/00313/2020 PTDC/QUI-OUT/29373/2017 POCI- 01-0145-FEDER-031032 FCT - PhD fellowship with the reference 2020.06768.BD national funds (OE), through FCT, I.P., within the scope of the framework contract foreseen in the numbers 4, 5 and 6 of the article 23, of the Decree-Law 57/2016, of August 29, changed by Law 57/2017, of July 19 |
Título da revista, periódico, livro ou evento: | Molecules | Volume: | 26 | Número: | 15 | Resumo: | Several classes of polysaccharides have been described to have hypocholesterolemic potential, namely cholesterol bioaccessibility and bioavailability. This review will highlight the main mechanisms by which polysaccharides are known to affect cholesterol homeostasis at the intestine, namely the effect (i) of polysaccharide viscosity and its influence on cholesterol bioaccessibility; (ii) on bile salt sequestration and its dependence on the structural diversity of polysaccharides; (iii) of bio-transformations of polysaccharides and bile salts by the gut microbiota. Different quantitative structure-hypocholesterolemic activity relationships have been explored depending on the mechanism involved, and these were based on polysaccharide physicochemical properties, such as sugar composition and ramification degree, linkage type, size/molecular weight, and charge. The information gathered will support the rationalization of polysaccharides' effect on cholesterol homeostasis and highlight predictive rules towards the development of customized hypocholesterolemic functional food. | URI: | https://hdl.handle.net/10316/105259 | ISSN: | 1420-3049 | DOI: | 10.3390/molecules26154559 | Direitos: | openAccess |
Aparece nas coleções: | FCTUC Química - Artigos em Revistas Internacionais |
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Ficheiro | Descrição | Tamanho | Formato | |
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Polysaccharide-structures-and-their-hypocholesterolemic-potentialMolecules.pdf | 1.01 MB | Adobe PDF | Ver/Abrir |
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