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https://hdl.handle.net/10316/103764
Título: | Macroautophagy and Mitophagy in Neurodegenerative Disorders: Focus on Therapeutic Interventions | Autor: | Magalhães, João Duarte Fão, Lígia Vilaça, Rita Cardoso, Sandra Morais Rego, A. Cristina |
Palavras-chave: | neurodegenerative disorders; autophagy; mitophagy mitochondrial dysfunction; mutant proteins; therapeutic strategies | Data: | 5-Nov-2021 | Editora: | MDPI | Projeto: | CENTRO-01-0145-FEDER-000012-HealthyAging 2020 POCI-01-0145-FEDER-032316 POCI-01-0145-FEDER-029621 POCI-01-0145-FEDER- 030712 PTDC/MED-NEU/3644/2020 UIDB/04539/2020 SFRH/BD/146409/2019 SFRH/BD/148263/2019 |
Título da revista, periódico, livro ou evento: | Biomedicines | Volume: | 9 | Número: | 11 | Resumo: | Macroautophagy, a quality control mechanism, is an evolutionarily conserved pathway of lysosomal degradation of protein aggregates, pathogens, and damaged organelles. As part of its vital homeostatic role, macroautophagy deregulation is associated with various human disorders, including neurodegenerative diseases. There are several lines of evidence that associate protein misfolding and mitochondrial dysfunction in the etiology of Alzheimer's, Parkinson's, and Huntington's diseases. Macroautophagy has been implicated in the degradation of different protein aggregates such as Aβ, tau, alpha-synuclein (α-syn), and mutant huntingtin (mHtt) and in the clearance of dysfunctional mitochondria. Taking these into consideration, targeting autophagy might represent an effective therapeutic strategy to eliminate protein aggregates and to improve mitochondrial function in these disorders. The present review describes our current understanding on the role of macroautophagy in neurodegenerative disorders and focuses on possible strategies for its therapeutic modulation. | URI: | https://hdl.handle.net/10316/103764 | ISSN: | 2227-9059 | DOI: | 10.3390/biomedicines9111625 | Direitos: | openAccess |
Aparece nas coleções: | I&D CNC - Artigos em Revistas Internacionais IIIUC - Artigos em Revistas Internacionais I&D CIBB - Artigos em Revistas Internacionais |
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Ficheiro | Descrição | Tamanho | Formato | |
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Macroautophagy-and-mitophagy-in-neurodegenerative-disorders-Focus-on-therapeutic-interventionsBiomedicines.pdf | 2.84 MB | Adobe PDF | Ver/Abrir |
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