Alves, C. Henrique

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Name
Alves, C. Henrique
 
Variants
Alves, C. Henrique
Alves, Celso Henrique
Alves, CH
 
 
Email
chalves@fmed.uc.pt
 
 
Status
UC Researcher
Biography
I graduated in Biochemistry (BSc) from the University of Beira Interior (Portugal) in 2005. In 2006, I was awarded a pre-doctoral fellowship for 30 months and during that period I obtained training in molecular and cell biology. Part of the work developed during that period was included in my MSc thesis, in Biochemistry (2008).
In 2014, I successfully completed my PhD in Neurosciences at the Netherlands Institute for Neurosciences (NIN, Amsterdam, The Netherlands). Regarding the PhD thesis, I was awarded the prestigious F.C. Donders prize. In 2014, I moved to the Erasmus University Medical Centre (EMC, Rotterdam, The Netherlands) for a post-doctoral position at Dr Erik Lubberts’ Lab in a collaboration with Prof. Björn Claussen (Mainz, Germany). There, I got skills and training in immunology.
In 2016, I returned to the retina field with the ambition of applying my new skills and knowledge in immunology to vision and gene therapy research. At the Leiden University Medical Center (LUMC, Leiden, The Netherlands), I worked on the characterization of rodent models for CRB1-retinopathies and I designed and tested AAV-mediated gene therapies to treat hereditary retinopathies.
In 2019, I moved to the Coimbra Institute for Clinical and Biomedical Research (ICBR, Coimbra, Portugal), to develop new therapeutical strategies for retinal degeneration based on the modulation of microglia activation and inflammatory processes.
I authored 27 papers in international peer-reviewed journals. Amongst these 27 papers, I am the last author in one, the second last author in 2, the first author in 12, the second author in 6 publications. Several manuscripts were published in some of the highest impact factor journals in the areas of Ophthalmology, Human Genetics, Stem Cells and Neurosciences, including Prog Retin Eye Res, PLoS Genet, PLoS Biol, J Neurosci, Stem Cell Reports, Acta Neuropathol Commun and Hum Mol Gen. I am also the author of 4 chapters in 4 international books. My early achievements track-record is mirrored by 5 abstracts selected for oral presentation at international congresses, and 7 invited presentations in national/international meetings, 4 international travel grants and 3 awards, including the Donders prize granted in 2016 for the best PhD thesis in the field of ophthalmology in the Netherlands and the Antioxidants 2020 Outstanding Reviewer Awards for excellence in manuscript review.
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Publications

Results 1-8 of 8 (Search time: 0.007 seconds).

Issue DateTitleAuthor(s)TypeAccess
1Mar-2020Crumbs2 mediates ventricular layer remodelling to form the spinal cord central canalTait, Christine M.; Chinnaiya, Kavitha; Manning, Elizabeth; Murtaza, Mariyam; Ashton, John-Paul; Furley, Nicholas; Hill, Chris J.; Alves, C. Henrique ; Wijnholds, Jan; Erdmann, Kai S.; Furley, Andrew; Rashbass, Penny; Das, Raman M.; Storey, Kate G.; Placzek, MarysiaarticleopenAccess
24-Mar-2021Cytotoxic Mechanism of Sphaerodactylomelol, an Uncommon Bromoditerpene Isolated from Sphaerococcus coronopifoliusAlves, Celso ; Silva, Joana; Pinteus, Susete; Alonso, Eva; Alvariño, Rebeca; Duarte, Adriana ; Marmitt, Diorge; Goettert, Márcia Inês; Gaspar, Helena ; Alfonso, Amparo; Alpoim, Maria C. ; Botana, Luis M.; Pedrosa, RuiarticleopenAccess
32018From Marine Origin to Therapeutics: The Antitumor Potential of Marine Algae-Derived CompoundsAlves, C. Henrique ; Silva, Joana; Pinteus, Susete; Gaspar, Helena ; Alpoim, Maria C. ; Botana, Luis M.; Pedrosa, RuiarticleopenAccess
413-May-2021IL-23 receptor deficiency results in lower bone mass via indirect regulation of bone formationRazawy, Wida; Alves, Celso H. ; Koedam, Marijke; Asmawidjaja, Patrick S.; Mus, Adriana M. C.; Oukka, Mohamed; Leenen, Pieter J. M.; Visser, Jenny A.; van der Eerden, Bram C. J.; Lubberts, ErikarticleopenAccess
52020PINK1/PARKIN signalling in neurodegeneration and neuroinflammationQuinn, Peter M. J.; Moreira, Paula I. ; Ambrósio, António Francisco ; Alves, C. Henrique articleopenAccess
6Aug-2020Sphaerococcus coronopifolius bromoterpenes as potential cancer stem cell-targeting agentsAlves, Celso H. ; Serrano, Eurico ; Silva, Joana; Rodrigues, Carlos ; Pinteus, Susete; Gaspar, Helena ; Botana, Luis M.; Alpoim, Maria C. ; Pedrosa, RuiarticleopenAccess
719-Nov-2021TRAP1 in Oxidative Stress and NeurodegenerationRego, Inês Ramos ; Cruz, Beatriz Santos ; Ambrósio, António Francisco ; Alves, Celso Henrique articleopenAccess
84-Feb-2023TRAP1 Is Expressed in Human Retinal Pigment Epithelial Cells and Is Required to Maintain their Energetic StatusRego, Inês Ramos ; Silvério, Daniela ; Eufrásio, Maria Isabel ; Pinhanços, Sandra Sofia ; Lopes da Costa, Bruna; Teixeira, José ; Fernandes, Hugo; Kong, Yang; Li, Yao; Tsang, Stephen H; Oliveira, Paulo J. ; Fernandes, Rosa ; Quinn, Peter M. J.; Santos, P. F. ; Ambrósio, António Francisco ; Alves, C. Henrique articleopenAccess