Carvalho, Luís A. E. Batista de
Claim profile
Loading...
2
0
20
0
false
Credit Name
Carvalho, Luís A. E. Batista de
Name
Carvalho, Luís Batista de
Variants
Carvalho, Luís A. E.
Carvalho, Luís A. E. Batista de
Carvalho, Luís A. E. Batista de
Unidade de I&D
Ciência ID
Researcher ID
Status
UC Researcher
Biography
Luís Alberto E. Batista de Carvalho (January 1961, Coimbra, Portugal) received his BSc (Hons) from the Department of Chemistry, Faculty of Science and Technology, University of Coimbra (1984) and his PhD in Chemistry, specialty Physical-Chemistry, from Faculty of Sciences, University of Lisbon (1993). He is currently associate professor at the Department of Chemistry, University of Coimbra and head of the “Molecular Physical-Chemistry” R&D Unit. Throughout his career he has developed several scientific research projects, in collaboration with national and international groups, in the areas of Medicinal Chemistry, Pharmaceutical Technology and Chemistry/Forensic Anthropology with special emphasis on the application of spectroscopic techniques: i) to the structural analysis of compounds of biological interest; ii) the development of new anti-cancer agents containing Pt and Pd (in particular, the determination of new therapeutic targets in order to optimize efficacy and minimize side effects and acquired resistance); iii) the study of drug/cell interactions in model systems (cancer cell lines) with a view to understanding the molecular mechanisms underlying cytotoxic activity; and iv) the analysis of changes induced by burning processes in human skeletons. He has preferably used vibrational spectroscopy, optical and with neutrons, including microRaman spectroscopy and FTIR with synchrotron radiation. Recently, and in conjunction with the aforementioned themes that he continues to develop, he started a research project that aims to apply vibrational spectroscopy techniques to the early diagnosis of cancer and rigorous determination of surgical margins (in the removal of malignant tumours). This subject involves not only methodological development but also the construction of a new Raman spectroscopy apparatus that increases the speed of diagnosis with a view to translate this technology to the clinics in the near future.
Loading...
3
0
20
0
false
Publications
(All)
Fulltext
Results 1-19 of 19 (Search time: 0.01 seconds).
| Issue Date | Title | Author(s) | Type | Access | |
|---|---|---|---|---|---|
| 1 | 2009 | 11th International Congress on Amino Acids, Peptides and Proteins | Marques, M. P. M. ; Costa, A. M. Amorim da ; Tomkinson, J. ; Calheiros, R. ; Carvalho, L. A. E. Batista de | article | openAccess |
| 2 | 2007 | Conformational and vibrational study of platinum(II) anticancer drugs: cis-diamminedichloroplatinum (II) as a case study | Amado, Ana M. ; Fiuza, Sónia M. ; Marques, Maria P. M. ; Carvalho, Luís A. E. Batista de | article | openAccess |
| 3 | 2008 | Conformational stability of ibuprofen: Assessed by DFT calculations and optical vibrational spectroscopy | Vueba, M. L. ; Pina, M. E. ; Carvalho, L. A. E. Batista de | article | openAccess |
| 4 | 2006 | Conformational study of ketoprofen by combined DFT calculations and Raman spectroscopy | Vueba, M. L. ; Pina, M. E. ; Veiga, F. ; Sousa, J. J. ; Carvalho, L. A. E. Batista de | article | openAccess |
| 5 | 2006 | Drug–excipient interactions in ketoprofen: A vibrational spectroscopy study | Carvalho, L. A. E. Batista de ; Marques, M. Paula M. ; Tomkinson, John | article | openAccess |
| 6 | 2007 | Effect of the Metal Center on the Antitumor Activity of the Analogous Dinuclear Spermine Chelates (PdCl2)2(Spermine) and (PtCl2)2(Spermine) | Soares, Ana ; Fiuza, Sónia ; Goncalves, M. ; Carvalho, Luís Batista de ; Marques, M. Paula ; Urbano, Ana M. | article | openAccess |
| 7 | 2000 | Effects of Carvedilol on Isolated Heart Mitochondria: Evidence for a Protonophoretic Mechanism | Oliveira, Paulo J. ; Marques, M. Paula M. ; Carvalho, Luís A. E. Batista de ; Moreno, A. J. M. | article | openAccess |
| 8 | 2006 | Influence of Cellulose Ether Mixtures on Ibuprofen Release: MC25, HPC and HPMC K100M | Vueba, M. L. ; Carvalho, L. A. E. Batista de ; Veiga, F. ; Sousa, J. J. ; Pina, M. E. | article | openAccess |
| 9 | 2004 | Influence of cellulose ether polymers on ketoprofen release from hydrophilic matrix tablets | Vueba, M. L. ; Carvalho, L. A. E. Batista de ; Veiga, F. ; Sousa, J. J. ; Pina, M. E. | article | openAccess |
| 10 | 2007 | INS Spectroscopy Study of Pt(II) and Pd(II) Polyamine Complexes Displaying Anticancer Activity | Marques, M. P. M. ; Tomkinson, J. ; Carvalho, L. A. E. Batista de | article | openAccess |
| 11 | 2004 | Intra- versus interchain interactions in α,ω-polyamines: a Raman spectroscopy study | Costa, A. M. Amorim da ; Marques, M. P. M ; Carvalho, L. A. E. Batista de | article | openAccess |
| 12 | 2003 | Raman spectra of putrescine, spermidine and spermine polyamines and their N-deuterated and N-ionized derivatives | Costa, A. M. Amorim da ; Marques, M. P. M. ; Carvalho, L. A. E. Batista de | article | openAccess |
| 13 | 2004 | Spectroscopic and Theoretical Studies on Solid 1,2-Ethylenediamine Dihydrochloride Salt | Amado, Ana M. ; Otero, Juan Carlos ; Marques, M. Paula M. ; Carvalho, Luís A. E. Batista de | article | openAccess |
| 14 | 21-Mar-2002 | Study of Biogenic and α,ω-Polyamines by Combined Inelastic Neutron Scattering and Raman Spectroscopies and by Ab Initio Molecular Orbital Calculations | Marques, M. Paula M. ; Carvalho, Luís A. E. Batista de ; Tomkinson, John | article | openAccess |
| 15 | 2002 | Study of carvedilol by combined Raman spectroscopy and ab initio MO calculations | Marques, M. P. M. ; Oliveira, P. J. ; Moreno, A. J. M. ; Carvalho, L. A. E. Batista de | article | openAccess |
| 16 | 2002 | The carbon---hydrogen stretching region of the Raman spectra of 1,6-hexanediamine: N-deuteration, ionisation and temperature effects | Costa, A. M. Amorim da ; Marques, M. P. M. ; Carvalho, L. A. E. Batista de | article | openAccess |
| 17 | 30-Nov-2006 | Transverse Acoustic Modes of Biogenic and α,ω-Polyamines: A Study by Inelastic Neutron Scattering and Raman Spectroscopies Coupled to DFT Calculations | Carvalho, Luís A. E. Batista de ; Marques, M. Paula M. ; Tomkinson, John | article | openAccess |
| 18 | 10-Apr-2008 | Use of Effective Core Potential Calculations for the Conformational and Vibrational Study of Platinum(II) Anticancer Drugs. cis-Diamminedichloroplatinum(II) as a Case Study | Fiuza, Sónia M. ; Amado, Ana M. ; Marques, Maria P. M. ; Carvalho, Luis A. E. Batista de | article | openAccess |
| 19 | 2007 | Vibrational spectroscopy studies on linear polyamines | Marques, M. P. M. ; Carvalho, L. A. E. Batista de | article | openAccess |