Please use this identifier to cite or link to this item:
Title: Drug–excipient interactions in ketoprofen: A vibrational spectroscopy study
Authors: Carvalho, L. A. E. Batista de 
Marques, M. Paula M. 
Tomkinson, John 
Keywords: Anti-Inflammatory Agents, Non-Steroidal; Elasticity; Excipients; Ketoprofen; Lactose; Neutron Diffraction; Povidone; Spectrum Analysis, Raman
Issue Date: 2006
Citation: Biopolymers. 82:4 (2006) 420-424
Serial title, monograph or event: Biopolymers
Volume: 82
Issue: 4
Abstract: Ketoprofen (3-benzoyl-alpha-methylbenzeneacetic acid) is a widely used nonsteroidal anti-inflammatory drug (NSAID), always administered in the form of drug-excipient physical mixtures (PMs). The occurrence of possible interactions between ketoprofen and two commonly used excipients-lactose (LAC) and polyvinylpyrrolidone (PVP)-was evaluated, through vibrational spectroscopy techniques [both Raman and Inelastic Neutron Scattering (INS)]. Spectral evidence of drug:excipient close contacts, which were enhanced by aging, was verified for the (1:1) (w:w) (ketoprofen:PVP) and (ketoprofen:LAC) PMs, both by Raman and INS. These interactions were found to involve mainly the central carbonyl and the terminal methyl-carboxylic moieties of the ketoprofen molecule, this being reflected in particular vibrational modes, such as the methyl torsion, the out-of-plane C-OH bending, and the inter-ring C=O stretching.
Other Identifiers: 10.1002/bip.20517
Rights: openAccess
Appears in Collections:FCTUC Ciências da Vida - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
BioP_06_82.pdf155.79 kBAdobe PDFView/Open
Show full item record

Page view(s) 20

checked on Mar 2, 2021


checked on Mar 2, 2021

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.