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Credit Name
Cunha-Oliveira, Teresa
 
Name
Cunha-Oliveira, Teresa
 
Variants
Oliveira, M.T.
Cunha-Oliveira, T.
Oliveira, T.C.
 
Email
teresa.oliveira@uc-biotech.pt
 
 
 
Scopus Author ID
 
Researcher ID
 
Status
UC Researcher
Biography
Teresa Cunha-Oliveira got her PhD in Biology (Cell Biology) in 2007 from the University of Coimbra (Portugal), having contributed to introduce the role of mitochondria in the field of drug addiction, particularly concerning cocaine, heroin and amphetamine. In her first post-doctoral period (2007-2010) in the Center for Neuroscience and Cell Biology (CNC, Coimbra), she collaborated with a Medicinal Chemistry group at the University of Porto to uncover the cellular effects of a newly found chemical interaction between heroin and cocaine (speedball) that could have a great impact in the understanding of poly-drug abuse consequences. In her second post-doctoral period (2010-2012), she was focused on the role of mitochondria in neurodegenerative diseases, including Huntington’s disease (HD) and Parkinson’s disease. She became interested in the epigenetic mechanisms associated with long-term mitochondrial dysfunction and contributed to characterize the bioenergetic dysfunction in cybrids from HD patients, evidencing the involvement of pyruvate dehydrogenase (PDH) and the promising role of epigenetic modulators in reversing PDH and mitochondrial dysfunctions in HD models. From 2013 until now, she is part of the MitoXT group at the CNC, more interested in the role of mitochondria in drug toxicology and experimental therapeutics, especially doxorubicin (DOX), an anticancer agent with long-term cardiotoxic side-effects involving mitochondria. She contributed to describe DOX-induced mitochondrial dysfunction, transcriptional deregulation and epigenetic signalling using in vitro and in vivo models. Her current interests include the development and validation of innovative screening assays to assess mitochondrial health with applications in toxicology, diagnostics and development of innovative therapeutic strategies for personalized medicine.
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Publications
(All)

Refined By:
Subject:  Apoptosis

Results 1-4 of 4 (Search time: 0.005 seconds).

Issue DateTitleAuthor(s)TypeAccess
12008Cellular and molecular mechanisms involved in the neurotoxicity of opioid and psychostimulant drugsCunha-Oliveira, Teresa ; Rego, Ana Cristina ; Oliveira, Catarina R. articleopenAccess
210-Mar-2022Evaluation of 6-Hydroxydopamine and Rotenone In Vitro Neurotoxicity on Differentiated SH-SY5Y Cells Using Applied Computational StatisticsSimões, Rui F. ; Oliveira, Paulo J. ; Oliveira, Teresa Cunha ; Pereira, Francisco B. articleopenAccess
3Dec-2014Mitochondrial apoptosis-inducing factor is involved in doxorubicin-induced toxicity on H9c2 cardiomyoblastsMoreira, Ana C. ; Branco, Ana F. ; Sampaio, Susana F. ; Cunha-Oliveira, Teresa ; Martins, Tatiana R. ; Holy, Jon ; Oliveira, Paulo J. ; Sardão, Vilma A. articleopenAccess
42014β-adrenergic over-stimulation and cardio-myocyte apoptosis: two receptors, one organelle, two fates?Branco, Ana F. ; Moreira, Ana C. ; Cunha-Oliveira, Teresa ; Couto, Renata ; Sardão, Vilma A. ; Rizvanov, Albert A. ; Palotas, Andras ; Oliveira, Paulo J. articleopenAccess