This research was funded by ERDF funds through the Operational Programme for Competitiveness (COMPETE 2020) and national funds by Foundation for Science and Technology under FCT Post-doctoral Fellowship (SPP, SFRH/BPD/116061/2016), FCT doctoral Fellowship (MSD, SFRH/BD/11934/2022), project grant PTDC/DTP-DES/1082/2014 (POCI-01-0145-FEDER-016657), CENTRO-01-0246-FEDER-000010 (Multidisciplinary Institute of Ageing in Coimbra), and strategic projects UIDB/04539/2020, UIDP/04539/2020, LA/P/0058/2020. Program Project Grant (P01) from the National Institutes of Health, USA [PO1-HD21350 to P.W.N., C.L. and M.J.N.] and R24 RR021367. Resources and facilities were also supported by the Southwest National Primate Research Center, San Antonio, TX, USA grant [P51-RR013986] from the National Center for Research Resources, NIH, currently supported by the Office of Research Infrastructure Programs through [P51-OD011133] and [C06-RR013556]. It was also funded by the European Union (HORIZON-HLTH-2022-STAYHLTH- 101080329).