Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/97079
Title: Anti-Inflammatory and Antiproliferative Properties of Sweet Cherry Phenolic-Rich Extracts
Authors: Gonçalves, Ana C. 
Costa, Ana R. 
Flores-Félix, José D.
Falcão, Amílcar 
Alves, Gilberto 
Silva, Luís R.
Keywords: Anti-inflammatory; Cytotoxicity; Oxidative stress; Phenolic compounds; Sweet cherries
Issue Date: 2-Jan-2022
Publisher: MDPI
Project: UIDP/00709/2020 
info:eu-repo/grantAgreement/EC/H2020/101003373/EU/NEW BIOFERTILIZER IN FUNTIONAL FOODS: EMPLOY OF LACTIC ACID BACTERIA AS VACCINIUM CORYMBOSUM INOCULANT 
UI/BD/151025/2021 
CENTRO-04-3559-FSE-000162 
UIDB/00709/2020 
POCI-01-0145-FEDER-022122 
2020.04947.BD 
Marie Skłodowska-Curie grant agreement No 101003373 
Serial title, monograph or event: Molecules
Volume: 27
Issue: 1
Abstract: Cherries have largely been investigated due to their high content in phenolics in order to fully explore their health-promoting properties. Therefore, this work aimed to assess, for the first time, the anti-inflammatory potential of phenolic-targeted fractions of the Saco cherry, using RAW 264.7 macrophages stimulated with lipopolysaccharide. Additionally, the cytotoxic effects on gastric adenocarcinoma (AGS), neuroblastoma (SH-SY5Y) and normal human dermal fibroblast (NHDF) cells were evaluated, as well as the ability to protect these cellular models against induced oxidative stress. The obtained data revealed that cherry fractions can interfere with cellular nitric oxide (NO) levels by capturing NO radicals and decreasing inducible nitric oxide synthase and cyclooxygenase-2 expression. Furthermore, it was observed that all cherry fractions exhibited dose-dependent cytotoxicity against AGS cells, presenting cytotoxic selectivity for these cancer cells when compared to SH-SY5Y and NHDF cells. Regarding their capacity to protect cancer cells against oxidative injury, in most assays, the total cherry extract was the most effective. Overall, this study reinforces the idea that sweet cherries can be incorporated into new pharmaceutical products, smart foods and nutraceuticals.
URI: http://hdl.handle.net/10316/97079
ISSN: 1420-3049
DOI: 10.3390/molecules27010268
Rights: openAccess
Appears in Collections:I&D CIBIT - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
molecules-27-00268.pdf2.58 MBAdobe PDFView/Open
Show full item record

WEB OF SCIENCETM
Citations

2
checked on Jul 2, 2022

Page view(s)

74
checked on Aug 6, 2022

Download(s)

22
checked on Aug 6, 2022

Google ScholarTM

Check

Altmetric

Altmetric


This item is licensed under a Creative Commons License Creative Commons