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Título: | A Fundamental Distinction in Early Neural Processing of Implicit Social Interpretation in Schizophrenia and Bipolar Disorder | Autor: | Madeira, Nuno Martins, Ricardo Filipe Alves Valente Duarte, João Costa, Gabriel Nascimento Ferreira da Macedo, António Ferreira de Castelo Branco, Miguel de Sá e Sousa |
Data: | Out-2021 | Editora: | Elsevier | Título da revista, periódico, livro ou evento: | NeuroImage: Clinical | Volume: | 32 | Resumo: | Background: Social cognition impairment is a key phenomenon in serious mental disorders such as schizophrenia (SCZ) and bipolar disorder (BPD). Although genetic and neurobiological studies have suggested common neural correlates, here we hypothesized that a fundamental dissociation of social processing occurs at an early level in these conditions. Methods: Based on the hypothesis that key structures in the social brain, namely the temporoparietal junction, should present distinctive features in SCZ and BPD during low-level social judgment, we conducted a case-control study in SCZ (n = 20) and BPD (n = 20) patients and controls (n = 20), using task-based fMRI during a Theory of Mind (ToM) visual paradigm leading to interpretation of social meaning based on simple geometric figures. Results: We found opposite neural responses in two core ToM regions: SCZ patients showed social content-related deactivation (relative to controls and BPD) of the right supramarginal gyrus, while the opposite pattern was found in BPD; reverse patterns, relative to controls and SCZ, were found in the left posterior superior temporal gyrus, a region involved in inferring other’s intentions. Receiver-operating-characteristic curve analysis showed 88% accuracy in discriminating the two clinical groups based on these neural responses. Conclusions: These contrasting activation patterns of the temporoparietal junction in SCZ and BPD represent mechanistic differences of social cognitive dysfunction that may be explored as biomarkers or therapeutic targets. | URI: | https://hdl.handle.net/10316/95864 | ISSN: | 22131582 | DOI: | 10.1016/j.nicl.2021.102836 | Direitos: | openAccess |
Aparece nas coleções: | I&D CIBIT - Artigos em Revistas Internacionais |
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