Please use this identifier to cite or link to this item: http://hdl.handle.net/10316/95769
Title: Unraveling the Photodynamic Activity of Cationic Benzoporphyrin-Based Photosensitizers against Bladder Cancer Cells
Authors: Gomes, Ana T. P. C.
Neves, M. Graça P. M. S. 
Fernandes, Rosa
Ribeiro, Carlos F. M. 
Cavaleiro, José A. S.
Moura, Nuno M. M.
Keywords: Benzoporphyrin; Cancer; Photodynamic therapy; Photosensitizer; Platinum complexes
Issue Date: 1-Sep-2021
Publisher: MDPI
Project: UIDB/04539/2020 
UIDB/50006/2020 
UIDP/04539/2020 
UID/NEU/04539/2019 
CDL-CTTRI-048-88-ARH/2018 
Serial title, monograph or event: Molecules
Volume: 26
Issue: 17
Abstract: In this study, we report the preparation of new mono-charged benzoporphyrin complexes by reaction of the appropriate neutral benzoporphyrin with (2,2'-bipyridine)dichloroplatinum(II) and of the analogs' derivatives synthesized through alkylation of the neutral scaffold with iodomethane. All derivatives were incorporated into polyvinylpyrrolidone (PVP) micelles. The ability of the resultant formulations to generate reactive oxygen species was evaluated, mainly the singlet oxygen formation. Then, the capability of the PVP formulations to act as photosensitizers against bladder cancer cells was assessed. Some of the studied formulations were the most active photosensitizers causing a decrease in HT-1376 cells' viability. This creates an avenue to further studies related to bladder cancer cells.
URI: http://hdl.handle.net/10316/95769
ISSN: 1420-3049
DOI: 10.3390/molecules26175312
Rights: openAccess
Appears in Collections:FMUC Medicina - Artigos em Revistas Internacionais

Files in This Item:
File Description SizeFormat
molecules-26-05312.pdf2.14 MBAdobe PDFView/Open
Show full item record

Page view(s)

25
checked on Oct 22, 2021

Download(s)

6
checked on Oct 22, 2021

Google ScholarTM

Check

Altmetric

Altmetric


This item is licensed under a Creative Commons License Creative Commons