Please use this identifier to cite or link to this item:
https://hdl.handle.net/10316/95769
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gomes, Ana T. P. C. | - |
dc.contributor.author | Neves, M. Graça P. M. S. | - |
dc.contributor.author | Fernandes, Rosa | - |
dc.contributor.author | Ribeiro, Carlos F. M. | - |
dc.contributor.author | Cavaleiro, José A. S. | - |
dc.contributor.author | Moura, Nuno M. M. | - |
dc.date.accessioned | 2021-09-16T15:49:04Z | - |
dc.date.available | 2021-09-16T15:49:04Z | - |
dc.date.issued | 2021-09-01 | - |
dc.identifier.issn | 1420-3049 | pt |
dc.identifier.uri | https://hdl.handle.net/10316/95769 | - |
dc.description.abstract | In this study, we report the preparation of new mono-charged benzoporphyrin complexes by reaction of the appropriate neutral benzoporphyrin with (2,2'-bipyridine)dichloroplatinum(II) and of the analogs' derivatives synthesized through alkylation of the neutral scaffold with iodomethane. All derivatives were incorporated into polyvinylpyrrolidone (PVP) micelles. The ability of the resultant formulations to generate reactive oxygen species was evaluated, mainly the singlet oxygen formation. Then, the capability of the PVP formulations to act as photosensitizers against bladder cancer cells was assessed. Some of the studied formulations were the most active photosensitizers causing a decrease in HT-1376 cells' viability. This creates an avenue to further studies related to bladder cancer cells. | pt |
dc.language.iso | eng | pt |
dc.publisher | MDPI | pt |
dc.relation | UIDB/04539/2020 | pt |
dc.relation | UIDB/50006/2020 | pt |
dc.relation | UIDP/04539/2020 | pt |
dc.relation | UID/NEU/04539/2019 | pt |
dc.relation | CDL-CTTRI-048-88-ARH/2018 | pt |
dc.rights | openAccess | pt |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt |
dc.subject | Benzoporphyrin | pt |
dc.subject | Cancer | pt |
dc.subject | Photodynamic therapy | pt |
dc.subject | Photosensitizer | pt |
dc.subject | Platinum complexes | pt |
dc.title | Unraveling the Photodynamic Activity of Cationic Benzoporphyrin-Based Photosensitizers against Bladder Cancer Cells | pt |
dc.type | article | - |
degois.publication.firstPage | 5312 | pt |
degois.publication.issue | 17 | pt |
degois.publication.title | Molecules | pt |
dc.peerreviewed | yes | pt |
dc.identifier.doi | 10.3390/molecules26175312 | pt |
degois.publication.volume | 26 | pt |
dc.date.embargo | 2021-09-01 | * |
uc.date.periodoEmbargo | 0 | pt |
item.fulltext | Com Texto completo | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology - CIBB | - |
crisitem.project.grantno | Associated Laboratory for Green Chemistry - Clean Technologies and Processes- REQUIMTE | - |
crisitem.project.grantno | Center for Innovative Biomedicine and Biotechnology | - |
crisitem.project.grantno | CNC. IBILI | - |
Appears in Collections: | I&D CIBB - Artigos em Revistas Internacionais FMUC Medicina - Artigos em Revistas Internacionais |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
molecules-26-05312.pdf | 2.14 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
3
checked on Oct 14, 2024
WEB OF SCIENCETM
Citations
3
checked on Oct 2, 2024
Page view(s)
180
checked on Oct 8, 2024
Download(s)
114
checked on Oct 8, 2024
Google ScholarTM
Check
Altmetric
Altmetric
This item is licensed under a Creative Commons License